PEP-1-GSTpi protein enhanced hippocampal neuronal cell survival after oxidative damage
DC Field | Value | Language |
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dc.contributor.author | Sohn, Eun Jeong | - |
dc.contributor.author | Shin, Min Jea | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Son, Ora | - |
dc.contributor.author | Jo, Hyo Sang | - |
dc.contributor.author | Bin Cho, Su | - |
dc.contributor.author | Park, Jung Hwan | - |
dc.contributor.author | Lee, Chi Hern | - |
dc.contributor.author | Yeo, Eun Ji | - |
dc.contributor.author | Choi, Yeon Joo | - |
dc.contributor.author | Yu, Yeon Hee | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Cho, Sung-Woo | - |
dc.contributor.author | Kwon, Oh Shin | - |
dc.contributor.author | Cho, Yong-Jun | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.accessioned | 2021-08-11T17:25:16Z | - |
dc.date.available | 2021-08-11T17:25:16Z | - |
dc.date.issued | 2016-07-31 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8931 | - |
dc.description.abstract | Reactive oxygen species generated under oxidative stress are involved in neuronal diseases, including ischemia. Glutathione S-transferase pi (GSTpi) is a member of the GST family and is known to play important roles in cell survival. We investigated the effect of GSTpi against oxidative stress-induced hippocampal HT-22 cell death, and its effects in an animal model of ischemic injury, using a cell-permeable PEP-1-GSTpi protein. PEP-1-GSTpi was transduced into HT-22 cells and significantly protected against H2O2-treated cell death by reducing the intracellular toxicity and regulating the signal pathways, including MAPK, Akt, Bax, and Bcl-2. PEP-1-GSTpi transduced into the hippocampus in animal brains, and markedly protected against neuronal cell death in an ischemic injury animal model. These results indicate that PEP-1-GSTpi acts as a regulator or an antioxidant to protect against oxidative stress-induced cell death. Our study suggests that PEP-1-GSTpi may have potential as a therapeutic agent for the treatment of ischemia and a variety of oxidative stress-related neuronal diseases. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | PEP-1-GSTpi protein enhanced hippocampal neuronal cell survival after oxidative damage | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2016.49.7.048 | - |
dc.identifier.scopusid | 2-s2.0-84991111264 | - |
dc.identifier.wosid | 000384757100006 | - |
dc.identifier.bibliographicCitation | BMB Reports, v.49, no.7, pp 382 - 387 | - |
dc.citation.title | BMB Reports | - |
dc.citation.volume | 49 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 382 | - |
dc.citation.endPage | 387 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002129556 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | GLUTATHIONE-S-TRANSFERASE | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | SPINAL-CORD | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | Apoptotic signals | - |
dc.subject.keywordAuthor | Ischemia | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | PEP-1-GSTpi | - |
dc.subject.keywordAuthor | Protein therapy | - |
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