Impact of Renin-Angiotensin System Inhibitors on Long-Term Clinical Outcomes of Patients With Coronary Artery Spasm
DC Field | Value | Language |
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dc.contributor.author | Choi, Byoung Geol | - |
dc.contributor.author | Jeon, Sung Yeon | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Park, Sang-Ho | - |
dc.contributor.author | Shim, Min Suk | - |
dc.contributor.author | Choi, Se Yeon | - |
dc.contributor.author | Byun, Jae Kyeong | - |
dc.contributor.author | Li, Hu | - |
dc.contributor.author | Choi, Jah Yeon | - |
dc.contributor.author | Park, Eun Jin | - |
dc.contributor.author | Park, Sung-Hun | - |
dc.contributor.author | Lee, Jae Joong | - |
dc.contributor.author | Lee, Sunki | - |
dc.contributor.author | Na, Jin Oh | - |
dc.contributor.author | Choi, Cheol Ung | - |
dc.contributor.author | Lim, Hong Euy | - |
dc.contributor.author | Kim, Jin Won | - |
dc.contributor.author | Kim, Eung Ju | - |
dc.contributor.author | Park, Chang Gyu | - |
dc.contributor.author | Seo, Hong Seog | - |
dc.contributor.author | Oh, Dong Joo | - |
dc.date.accessioned | 2021-08-11T17:25:56Z | - |
dc.date.available | 2021-08-11T17:25:56Z | - |
dc.date.issued | 2016-07 | - |
dc.identifier.issn | 2047-9980 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8998 | - |
dc.description.abstract | Background-Coronary artery spasm (CAS) is a well-known endothelial dysfunction, and a major cause of vasospastic angina (VSA). The renin-angiotensin system (RAS) is known to be closely associated with endothelial function. However, there are only a few studies that investigated the impact of RAS inhibitor on long-term clinical outcomes in VSA patients. Methods and Results-A total of 3349 patients with no significant coronary artery disease, diagnosed with CAS by acetylcholine provocation test were enrolled for this study. Significant CAS was defined as having >= 70% narrowing of the artery after incremental injections of 20, 50, and 100 mu g of acetylcholine into the left coronary artery. Patients were divided into 2 groups according to whether the prescription included RAS inhibitor or not (RAS inhibitor group: n=666, non-RAS inhibitor group; n=2683). To adjust for any potential confounders that could cause bias, propensity score matching (PSM) analysis was performed using a logistic regression model. After PSM analysis, 2 matched groups (524 pairs, n=1048 patients, C-statistic=0.845) were generated and their baseline characteristics were balanced. During the 5-year clinical follow-up, the RAS inhibitor group showed a lower incidence of recurrent angina (8.7% versus 14.1%, P=0.027), total death (0.0% versus 1.3%, P=0.045), and total major adverse cardiovascular events (1.0% versus 4.1%, P=0.026) than the non-RAS inhibitor group. Conclusions-Chronic RAS inhibitor therapy was associated with lower incidence of cardiovascular events in VSA patients in the 5-year clinical follow-up. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Wiley-Blackwell | - |
dc.title | Impact of Renin-Angiotensin System Inhibitors on Long-Term Clinical Outcomes of Patients With Coronary Artery Spasm | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1161/JAHA.116.003217 | - |
dc.identifier.wosid | 000386713800017 | - |
dc.identifier.bibliographicCitation | Journal of the American Heart Association, v.5, no.7 | - |
dc.citation.title | Journal of the American Heart Association | - |
dc.citation.volume | 5 | - |
dc.citation.number | 7 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | VASOSPASTIC ANGINA | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordAuthor | acetylcholine | - |
dc.subject.keywordAuthor | angina | - |
dc.subject.keywordAuthor | angiotensin converting enzyme inhibitor | - |
dc.subject.keywordAuthor | angiotensin receptor blocker | - |
dc.subject.keywordAuthor | coronary artery spasm | - |
dc.subject.keywordAuthor | renin-angiotensin system | - |
dc.subject.keywordAuthor | vasospasm | - |
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