Management of Endometrial Hyperplasia With a Levonorgestrel-Releasing Intrauterine System A Korean Gynecologic-Oncology Group Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Mi Kyoung | - |
dc.contributor.author | Seong, Seok Ju | - |
dc.contributor.author | Kim, Jae-Weon | - |
dc.contributor.author | Jeon, Seob | - |
dc.contributor.author | Choi, Ho Sun | - |
dc.contributor.author | Lee, In-Ho | - |
dc.contributor.author | Lee, Jong Hak | - |
dc.contributor.author | Ju, Woong | - |
dc.contributor.author | Song, Eun Seop | - |
dc.contributor.author | Park, Hyun | - |
dc.contributor.author | Ryu, Hee-Sug | - |
dc.contributor.author | Lee, Chulmin | - |
dc.contributor.author | Kang, Soon-Beom | - |
dc.date.accessioned | 2021-08-11T17:44:54Z | - |
dc.date.available | 2021-08-11T17:44:54Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 1048-891X | - |
dc.identifier.issn | 1525-1438 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9180 | - |
dc.description.abstract | Objective: The aim of the study was to evaluate the efficacy of the levonorgestrel intrauterine system (LNG-IUS) for treatment of endometrial hyperplasia (EH). Methods: A prospective multicenter study was conducted from November 2010 to March 2014. Patients with histologically confirmed EH were treated with LNG-IUS. At 3, 6, and 9 months after LNG-IUS insertion, follow-up endometrial aspiration biopsies with the LNG-IUS in the uterus were undertaken. At the 12th month of follow-up, endometrial tissues were obtained via 2 methods: endometrial aspiration biopsy with the LNG-IUS in the uterus, followed by dilatation and curettage (D&C) after LNG-IUS removal. The primary outcome was the regression rate at 12 months after LNG-IUS insertion, and the secondary outcome was the consistency of the results between the endometrial aspiration biopsy and the D&C. Results: The study population comprised 75 patients, including 37 with simple hyperplasia without atypia; 3 with atypical simple hyperplasia; 23 with complex hyperplasia without atypia, and 12 with atypical complex hyperplasia. Of these patients treated with the LNGIUS, 38 (50.7%) were followed up at 12 months after LNG-IUS insertion. The complete regression rate at 12 months was 94.7% (36/38): 100% (6/6) of patients with atypical EH and 93.7% (30/32) with EH without atypia. In all of the cases (100%, 36/36), patients achieved complete regression within 3 months of LNG-IUS insertion. A comparison of the pathologic results from endometrial aspiration biopsy and D&C was carried out for 15 patients. In the histologic results by endometrial aspiration biopsy, 14 patients were diagnosed as "normal endometrium" and 1 as "insufficient tissue for pathologic evaluation." Among the 14 cases of normal endometrium by endometrial aspiration biopsy, 1 was diagnosed as "residual EH" by D&C, and the 1 case with insufficient tissue was diagnosed as normal endometrium by D&C. Conclusions: Levonorgestrel intrauterine system is an effective and favorable method for treatment of EH. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Management of Endometrial Hyperplasia With a Levonorgestrel-Releasing Intrauterine System A Korean Gynecologic-Oncology Group Study | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1097/IGC.0000000000000669 | - |
dc.identifier.scopusid | 2-s2.0-84965179403 | - |
dc.identifier.wosid | 000377146600016 | - |
dc.identifier.bibliographicCitation | International Journal of Gynecological Cancer, v.26, no.4, pp 711 - 715 | - |
dc.citation.title | International Journal of Gynecological Cancer | - |
dc.citation.volume | 26 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 711 | - |
dc.citation.endPage | 715 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.subject.keywordPlus | TERM-FOLLOW-UP | - |
dc.subject.keywordPlus | LONG-TERM | - |
dc.subject.keywordPlus | LNG-IUS | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | DILATATION | - |
dc.subject.keywordPlus | CURETTAGE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordAuthor | Endometrial hyperplasia | - |
dc.subject.keywordAuthor | Progesterone | - |
dc.subject.keywordAuthor | LNG-IUS | - |
dc.subject.keywordAuthor | Dilatation and curettage | - |
dc.subject.keywordAuthor | Endometrial aspiration biopsy | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.