ENHANCEMENT OF SMALL MOLECULE DELIVERY BY PULSED HIGH-INTENSITY FOCUSED ULTRASOUND: A PARAMETER EXPLORATION
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhou, Yufeng | - |
dc.contributor.author | Wang, Yak-Nam | - |
dc.contributor.author | Farr, Navid | - |
dc.contributor.author | Zia, Jasmine | - |
dc.contributor.author | Chen, Hong | - |
dc.contributor.author | Ko, Bong Min | - |
dc.contributor.author | Khokhlova, Tatiana | - |
dc.contributor.author | Li, Tong | - |
dc.contributor.author | Hwang, Joo Ha | - |
dc.date.accessioned | 2021-08-11T17:45:24Z | - |
dc.date.available | 2021-08-11T17:45:24Z | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 0301-5629 | - |
dc.identifier.issn | 1879-291X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9234 | - |
dc.description.abstract | Chemotherapeutic drug delivery is often ineffective within solid tumors, but increasing the drug dose would result in systemic toxicity. The use of high-intensity focused ultrasound (HIFU) has the potential to enhance penetration of small molecules. However, operation parameters need to be optimized before the use of chemotherapeutic drugs in vivo and translation to clinical trials. In this study, the effects of pulsed HIFU (pHIFU) parameters (spatial-average pulse-average intensity, duty factor and pulse repetition frequency) on the penetration as well as content of small molecules were evaluated in ex vivo porcine kidneys. Specific HIFU parameters resulted in more than 40 times greater Evans blue content and 3.5 times the penetration depth compared with untreated samples. When selected parameters were applied to porcine kidneys in vivo, a 2.3-fold increase in concentration was obtained after a 2-min exposure to pHIFU. Pulsed HIFU has been found to be an effective modality to enhance both the concentration and penetration depth of small molecules in tissue using the optimized HIFU parameters. Although, performed in normal tissue, this study has the promise of translation into tumor tissue. (E-mail: ynwang@u.washington.edu) (C) 2016 World Federation for Ultrasound in Medicine & Biology. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | ENHANCEMENT OF SMALL MOLECULE DELIVERY BY PULSED HIGH-INTENSITY FOCUSED ULTRASOUND: A PARAMETER EXPLORATION | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.ultrasmedbio.2015.12.009 | - |
dc.identifier.scopusid | 2-s2.0-84961285668 | - |
dc.identifier.wosid | 000373384700014 | - |
dc.identifier.bibliographicCitation | Ultrasound in Medicine and Biology, v.42, no.4, pp 956 - 963 | - |
dc.citation.title | Ultrasound in Medicine and Biology | - |
dc.citation.volume | 42 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 956 | - |
dc.citation.endPage | 963 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Acoustics | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Acoustics | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | SOLID TUMORS | - |
dc.subject.keywordPlus | PANCREATIC-CANCER | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordAuthor | Pulsed-high intensity focused ultrasound | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | Content and penetration | - |
dc.subject.keywordAuthor | Ultrasound parameters | - |
dc.subject.keywordAuthor | Kidney | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.