Clinical Effects and Safety of 3% Diquafosol Ophthalmic Solution for Patients With Dry Eye After Cataract Surgery: A Randomized Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | Park, Dae Hyun | - |
dc.contributor.author | Chung, Jin Kwon | - |
dc.contributor.author | Seo, Du Ri | - |
dc.contributor.author | Lee, Sung Jin | - |
dc.date.accessioned | 2021-08-11T17:46:12Z | - |
dc.date.available | 2021-08-11T17:46:12Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 0002-9394 | - |
dc.identifier.issn | 1879-1891 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9317 | - |
dc.description.abstract | PURPOSE: To compare the efficacies and safety profiles of 3% diquafosol and 0.1% sodium hyaluronate in patients with dry eye after cataract surgery. DESIGN: Randomized controlled trial. METHODS: SETTING: Soonchunhyang University Hospital, Seoul, South Korea. STUDY POPULATION: In all, 130 eyes of 86 dry eye patients who had undergone cataract surgery between January 2014 and January 2015 were enrolled and randomly divided into a diquafosol group and a sodium hyaluronate group. INTERVENTION: The diquafosol group used diquafosol 6 times a day and the hyaluronate group used sodium hyaluronate 6 times a day after cataract surgery. MAIN OUTCOME MEASURES: Evaluations of efficacy were conducted based on an Ocular Surface Disease Index questionnaire, tear breakup time (TBUT), Schirmer I test, corneal fluorescein and conjunctival lissamine green staining scores, serial measurement of ocular higher-order aberrations (HOAs), corneal HOAs, and uncorrected distance visual acuity test. Safety evaluations were based on anterior chamber inflammation and discontinuation of the eye drops. RESULTS: Objective signs and subjective symptoms were aggravated at 1 week postoperatively and began to recover significantly 4 weeks after surgery. The diquafosol group showed significantly superior TBUT (P<.001), corneal fluorescein (P=.045), and conjunctival staining (P=.001) compared to the sodium hyaluronate group throughout the study period. TBUT (P<.001) and the change in HOAs (P=.018) recovered significantly more quickly in the diquafosol group. The safety evaluations showed no intergroup differences. CONCLUSIONS: Eye drops of 3% diquafosol may be an effective and safe treatment for the management of cataract surgery-induced dry eye aggravation in patients with preexisting dry eye. (C) 2016 by Elsevier Inc. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Clinical Effects and Safety of 3% Diquafosol Ophthalmic Solution for Patients With Dry Eye After Cataract Surgery: A Randomized Controlled Trial | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.ajo.2015.12.002 | - |
dc.identifier.scopusid | 2-s2.0-84959180800 | - |
dc.identifier.wosid | 000371447500017 | - |
dc.identifier.bibliographicCitation | American Journal of Ophthalmology, v.163, pp 122 - 131 | - |
dc.citation.title | American Journal of Ophthalmology | - |
dc.citation.volume | 163 | - |
dc.citation.startPage | 122 | - |
dc.citation.endPage | 131 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | HIGHER-ORDER ABERRATIONS | - |
dc.subject.keywordPlus | HYALURONIC-ACID | - |
dc.subject.keywordPlus | OCULAR SURFACE | - |
dc.subject.keywordPlus | CORNEAL | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INS365 | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | WORKSHOP | - |
dc.subject.keywordAuthor | Clinical Effects and Safety of 3% Diquafosol Ophthalmic Solution for Patients With Dry Eye After Cataract Surgery: A Randomized Controlled Trial. | - |
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