Increased risk for development of coronary artery calcification in insulin-resistant subjects who developed diabetes: 4-year longitudinal study
DC Field | Value | Language |
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dc.contributor.author | Rhee, Eun-Jung | - |
dc.contributor.author | Kim, Ji Hyun | - |
dc.contributor.author | Park, Hye-Jeong | - |
dc.contributor.author | Park, Se Eun | - |
dc.contributor.author | Oh, Hyung-Geun | - |
dc.contributor.author | Park, Cheol-Young | - |
dc.contributor.author | Lee, Won-Young | - |
dc.contributor.author | Oh, Ki-Won | - |
dc.contributor.author | Park, Sung-Woo | - |
dc.date.accessioned | 2021-08-11T18:24:02Z | - |
dc.date.available | 2021-08-11T18:24:02Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.issn | 1879-1484 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9396 | - |
dc.description.abstract | Objective: Coronary artery calcification (CAC) is considered a surrogate marker for atherosclerotic burden. The aim of this study was to analyze the risk of incident CAC associated with diabetes development in non-diabetic subjects with zero CAC score (CACS) at baseline. Methods: 2076 non-diabetic participants (mean age 40 years) in a health screening program in whom CACS were repeatedly measured by multi-detector computed tomography in four years of intervals and with zero CACS at baseline, were retrospectively analyzed. Glycemic status was assessed in both years, with subjects divided into three groups: subjects with 'no progression', 'normal to impaired fasting glucose (IFG)' and 'progression to diabetes'. Insulin resistance was assessed by homeostasis model assessment-insulin resistance (HOMA-IR) index. Results: Over 4 years, 204 subjects (9.8%) developed CAC. Subjects who developed diabetes showed the highest proportion of subjects with incident CAC among the three groups (21.0% vs. 9.3 and 10.4% in non-progressors and subjects from normal to IFG). The subjects with HOMA-IR level in higher half at baseline showed significantly increased risk for incident CAC in subjects who progressed from normal to IFG and in subjects who developed diabetes (1.740; 95% CI 1.014-2.985, 2.449; 95% CI 1.159-5.174) even after adjustment for confounding variables, whereas subjects with HOMA-IR level in lower half at baseline showed no significantly increased risk for incident CAC even in subjects who developed diabetes. Conclusions: In this non-diabetic population, we found that increased risk for incident CAC in relation to diabetes development over 4 years was pronounced only in subjects with insulin resistance at baseline. (C) 2015 Elsevier Ireland Ltd. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Increased risk for development of coronary artery calcification in insulin-resistant subjects who developed diabetes: 4-year longitudinal study | - |
dc.type | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2015.12.010 | - |
dc.identifier.scopusid | 2-s2.0-84951763914 | - |
dc.identifier.wosid | 000368982400041 | - |
dc.identifier.bibliographicCitation | Atherosclerosis, v.245, pp 132 - 138 | - |
dc.citation.title | Atherosclerosis | - |
dc.citation.volume | 245 | - |
dc.citation.startPage | 132 | - |
dc.citation.endPage | 138 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | BEAM COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | PREDICTOR | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | SCORE | - |
dc.subject.keywordAuthor | Coronary artery calcification | - |
dc.subject.keywordAuthor | Insulin resistance | - |
dc.subject.keywordAuthor | Glycemic progression | - |
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