Cryptotanshinone, a compound of Salvia miltiorrhiza inhibits pre-adipocytes differentiation by regulation of adipogenesis-related genes expression via STAT3 signaling
DC Field | Value | Language |
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dc.contributor.author | Rahman, Naimur | - |
dc.contributor.author | Jeon, Miso | - |
dc.contributor.author | Song, Ho-Yeon | - |
dc.contributor.author | Kim, Yong-Sik | - |
dc.date.accessioned | 2021-08-11T18:24:22Z | - |
dc.date.available | 2021-08-11T18:24:22Z | - |
dc.date.issued | 2016-01-15 | - |
dc.identifier.issn | 0944-7113 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9416 | - |
dc.description.abstract | Background: Cryptotanshinone (CT), a major tanshinone found in Salvia rrtitliorrhiza Bunge (Lcniacecie), has various pharmacological effects such as antitumor, anti-inflammatory, and antioxidant properties. Despite its well-documented benefits in a wide range of diseases, the effect of CT on adipocyte differentiation has not been well characterized. Purpose: The present study was designed to determine the in vitro anti-adipogenic effect and underlying molecular mechanisms of CT using 3T3-L1 murine pre-adipocytes. Methods: We measured the levels of intracellular triglyceride accumulation and mRNA and protein expression of key adipogenic transcription factors and their target genes. Results: Treatment with CT drastically reduced lipid accumulation in a dose-and time-dependent manner. Molecular assays showed that CT effectively suppressed the expression of C/EBP beta, C/EBP alpha, and PPAR gamma and of theft target adipocyte-specific genes aP2, adiponectin, and GUIT4 but activated the expression of anti-adipogenic genes such as GATA2, CH0P10, and TNT-alpha. CT treatment also inhibited the phosphorylation of STAT3 in the early phase of adipogenesis. A small-interfering-RNA-mediated knockdown of STAT3 potentiated the anti-adipogenic effect of CT. Conclusion: Taken together, the results suggest that CT may be a good anti-adipogenic candidate because it regulates STAT3 during early adipogenesis. (C) 2015 Elsevier GmbH. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Cryptotanshinone, a compound of Salvia miltiorrhiza inhibits pre-adipocytes differentiation by regulation of adipogenesis-related genes expression via STAT3 signaling | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1016/j.phymed.2015.12.004 | - |
dc.identifier.scopusid | 2-s2.0-84954285998 | - |
dc.identifier.wosid | 000370415900009 | - |
dc.identifier.bibliographicCitation | Phytomedicine, v.23, no.1, pp 58 - 67 | - |
dc.citation.title | Phytomedicine | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 58 | - |
dc.citation.endPage | 67 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | DIET-INDUCED OBESITY | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | RETINOIC ACID | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CONVERSION | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordAuthor | Crypiolanshinoi | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordAuthor | C/EBP beta | - |
dc.subject.keywordAuthor | PPAR gamma | - |
dc.subject.keywordAuthor | STAT3 | - |
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