지연 이식신기능을 일으킨 공여자 이식신 혈전증 1예Delayed Graft Function Is Associated with Microvascular Thrombosis in a Donor with Disseminated Intravascular Coagulation
- Other Titles
- Delayed Graft Function Is Associated with Microvascular Thrombosis in a Donor with Disseminated Intravascular Coagulation
- Authors
- 조윤주; 위지완; 권순효; 전진석; 노현진; 한동철; 송단; 진소영
- Issue Date
- 2016
- Publisher
- 대한이식학회
- Keywords
- 지연 이식신기능; 파종혈관내응고; 혈전증; Delayed graft function; Disseminated intravascular coagulation; Thrombosis
- Citation
- 대한이식학회지, v.30, no.1, pp 31 - 34
- Pages
- 4
- Journal Title
- 대한이식학회지
- Volume
- 30
- Number
- 1
- Start Page
- 31
- End Page
- 34
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9850
- ISSN
- 1598-1711
2508-2604
- Abstract
- Microvascular thrombosis is an uncommon pathological finding in deceased donor kidneys. It is associated with disseminated intravascular coagulation (DIC) after brain injury in the donor. Although DIC in deceased kidney donors is known to have no association with graft outcome, microvascular thrombosis with DIC in a donor can cause renal graft impairment. For this reason, some transplantation centers do not accept these kidneys. A 39-year-old female donor had a subarachnoid hemorrhage. After a short period of cardiopulmonary resuscitation, we applied extracorporeal membrane oxygenation to maintain hemodynamic stability.
The laboratory data were consistent with DIC. The recipient was a 38-year-old male patient who had been undergoing hemodialysis for 7 years because of end-stage renal disease of unknown cause. Zero-time graft biopsy revealed multiple intraluminal fibrin thrombi without peritubular capillaritis. Delayed graft function occurred after transplantation, and hemodialysis was started. Graft renal biopsy was performed on the third day after transplantation. The percentage of intraglomerular fibrin thrombi had decreased, and no significant peritubular capillaritis or C4d staining was observed. The function of the transplanted kidney started to recover, and hemodialysis was discontinued on the 10th day after surgery without specific treatment. Follow-up biopsy performed 20 days after the transplantation revealed normal kidney with completely resolved fibrin thrombi. We report herein a case of microvascular thrombosis in renal allograft from a DIC donor.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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