Primary Adrenal Insufficiency in a Newborn With Adrenal Hypoplasia Congenita Caused by a Mutation of the DAX1 GenePrimary Adrenal Insufficiency in a Newborn With Adrenal Hypoplasia Congenita Caused by a Mutation of the DAX1 Gene
- Other Titles
- Primary Adrenal Insufficiency in a Newborn With Adrenal Hypoplasia Congenita Caused by a Mutation of the DAX1 Gene
- Authors
- 박선형; 홍용희; 김성신
- Issue Date
- 2016
- Publisher
- 대한신생아학회
- Keywords
- Adrenal hyperplasia congenita; Adrenal insufficiency; Infant newborn
- Citation
- Neonatal medicine, v.23, no.1, pp 53 - 58
- Pages
- 6
- Journal Title
- Neonatal medicine
- Volume
- 23
- Number
- 1
- Start Page
- 53
- End Page
- 58
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9887
- ISSN
- 2287-9412
2287-9803
- Abstract
- Adrenal hypoplasia congenita (AHC) is a rare inherited disorder of the adrenal gland caused by deletion or mutation of the dosage-sensitive sex-reversal AHC critical region on the X chromosome, gene 1 (DAX1) gene. The DAX1 gene is expressed in the adrenal cortex, the pituitary gland, the hypothalamus, the testis, and the ovary. Most affected infants present with failure to thrive, salt wasting, and hypoglycemic seizure in early life. Immediate mineralocorticoid and glucocorticoid replacement is essen- tial. Most boys with AHC present with hypogonadotropic hypogonadism, resulting in failure to enter puberty and the need for testosterone treatment. However, a recent study revealed that the onset of puberty in boys with AHC can be variable, ranging from arrested or absent to precocious. We describe a case involving a newborn who presented with primary adrenal insufficiency due to a mutation of the DAX1 gene and was finally diagnosed with AHC.
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