Differences in Depressive Patterns According to Disease Severity in Early-Onset Alzheimer's Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Bora | - |
dc.contributor.author | Yang, Dong Won | - |
dc.contributor.author | Hong, Yun Jeong | - |
dc.contributor.author | Choi, Seong Hye | - |
dc.contributor.author | Park, Sun Ah | - |
dc.contributor.author | Park, Hee Kyung | - |
dc.contributor.author | Kim, Yong Duk | - |
dc.contributor.author | Shim, Yong S. | - |
dc.date.accessioned | 2021-08-11T18:45:53Z | - |
dc.date.available | 2021-08-11T18:45:53Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.issn | 1875-8908 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9932 | - |
dc.description.abstract | Background & Objective: Depression frequently combines with dementia, including early-onset Alzheimer's disease (EOAD). We investigated differences in prevalence and characteristics of depressive symptoms according to dementia severity in EOAD patients. Methods: The 15-item Korean version of the Geriatric Depression Scale (GDS-15) was administered to 412 EOAD patients. Factor analysis was used to assess GDS-15 factor structure. We subdivided participants into three groups by disease severity, then compared the frequencies and scores of individual GDS-15 items and performed logistic regression analysis to assess associations between depressive symptoms and EOAD stage. Results: Factor analysis yielded three factor categories: 1) "hopelessness and ominousness" (symptoms no. 6, 8, 12, 14, 15); 2) "unhappiness and dissatisfaction" (no. 1, 3, 5, 7, 11); and 3) "monotony and lack of energy" (no. 2, 4, 9, 10, 13). Factor 2 depressive symptoms (no. 1, 5, 11) were less common in moderate EOAD. The risk of Factor 1 symptoms: no. 12 (OR, 2.04; 95% CI, 1.19-3.50; p = 0.010) and 14 (OR, 1.84; 95% CI, 1.07-3.16; p = 0.028) was higher in mild than very mild EOAD. The risk of Factor 2 symptoms: no. 9 (OR, 2.69; 95% CI, 1.08-6.71; p = 0.033) and 13 (OR, 2.12; 95% CI, 1.02-4.40; p = 0.043) was higher in moderate than mild EOAD. Conclusion: We confirmed that depressive symptoms differ according to EOAD severity. When assessing depressive symptoms related to dementia progression, we recommend focusing on "hopelessness and ominousness" in very mild EOAD and "unhappiness and dissatisfaction" in mild EOAD. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | IOS Press | - |
dc.title | Differences in Depressive Patterns According to Disease Severity in Early-Onset Alzheimer's Disease | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.3233/JAD-150703 | - |
dc.identifier.scopusid | 2-s2.0-84973165168 | - |
dc.identifier.wosid | 000375008500009 | - |
dc.identifier.bibliographicCitation | Journal of Alzheimer's Disease, v.52, no.1, pp 91 - 99 | - |
dc.citation.title | Journal of Alzheimer's Disease | - |
dc.citation.volume | 52 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 91 | - |
dc.citation.endPage | 99 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | MILD COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | LATE-LIFE DEPRESSION | - |
dc.subject.keywordPlus | NEUROPSYCHIATRIC-SYMPTOMS | - |
dc.subject.keywordPlus | CLINICAL CHARACTERISTICS | - |
dc.subject.keywordPlus | PSYCHOLOGICAL SYMPTOMS | - |
dc.subject.keywordPlus | BEHAVIORAL SYMPTOMS | - |
dc.subject.keywordPlus | NURSING-HOMES | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Alzheimer's disease | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | disease progression | - |
dc.subject.keywordAuthor | early-onset | - |
dc.subject.keywordAuthor | geriatric depression scale | - |
dc.subject.keywordAuthor | prediction | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.