Detailed Information

Cited 0 time in webofscience Cited 3 time in scopus
Metadata Downloads

Differences in Depressive Patterns According to Disease Severity in Early-Onset Alzheimer's Disease

Full metadata record
DC Field Value Language
dc.contributor.authorYoon, Bora-
dc.contributor.authorYang, Dong Won-
dc.contributor.authorHong, Yun Jeong-
dc.contributor.authorChoi, Seong Hye-
dc.contributor.authorPark, Sun Ah-
dc.contributor.authorPark, Hee Kyung-
dc.contributor.authorKim, Yong Duk-
dc.contributor.authorShim, Yong S.-
dc.date.accessioned2021-08-11T18:45:53Z-
dc.date.available2021-08-11T18:45:53Z-
dc.date.issued2016-
dc.identifier.issn1387-2877-
dc.identifier.issn1875-8908-
dc.identifier.urihttps://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9932-
dc.description.abstractBackground & Objective: Depression frequently combines with dementia, including early-onset Alzheimer's disease (EOAD). We investigated differences in prevalence and characteristics of depressive symptoms according to dementia severity in EOAD patients. Methods: The 15-item Korean version of the Geriatric Depression Scale (GDS-15) was administered to 412 EOAD patients. Factor analysis was used to assess GDS-15 factor structure. We subdivided participants into three groups by disease severity, then compared the frequencies and scores of individual GDS-15 items and performed logistic regression analysis to assess associations between depressive symptoms and EOAD stage. Results: Factor analysis yielded three factor categories: 1) "hopelessness and ominousness" (symptoms no. 6, 8, 12, 14, 15); 2) "unhappiness and dissatisfaction" (no. 1, 3, 5, 7, 11); and 3) "monotony and lack of energy" (no. 2, 4, 9, 10, 13). Factor 2 depressive symptoms (no. 1, 5, 11) were less common in moderate EOAD. The risk of Factor 1 symptoms: no. 12 (OR, 2.04; 95% CI, 1.19-3.50; p = 0.010) and 14 (OR, 1.84; 95% CI, 1.07-3.16; p = 0.028) was higher in mild than very mild EOAD. The risk of Factor 2 symptoms: no. 9 (OR, 2.69; 95% CI, 1.08-6.71; p = 0.033) and 13 (OR, 2.12; 95% CI, 1.02-4.40; p = 0.043) was higher in moderate than mild EOAD. Conclusion: We confirmed that depressive symptoms differ according to EOAD severity. When assessing depressive symptoms related to dementia progression, we recommend focusing on "hopelessness and ominousness" in very mild EOAD and "unhappiness and dissatisfaction" in mild EOAD.-
dc.format.extent9-
dc.language영어-
dc.language.isoENG-
dc.publisherIOS Press-
dc.titleDifferences in Depressive Patterns According to Disease Severity in Early-Onset Alzheimer's Disease-
dc.typeArticle-
dc.publisher.location네델란드-
dc.identifier.doi10.3233/JAD-150703-
dc.identifier.scopusid2-s2.0-84973165168-
dc.identifier.wosid000375008500009-
dc.identifier.bibliographicCitationJournal of Alzheimer's Disease, v.52, no.1, pp 91 - 99-
dc.citation.titleJournal of Alzheimer's Disease-
dc.citation.volume52-
dc.citation.number1-
dc.citation.startPage91-
dc.citation.endPage99-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.subject.keywordPlusMILD COGNITIVE IMPAIRMENT-
dc.subject.keywordPlusLATE-LIFE DEPRESSION-
dc.subject.keywordPlusNEUROPSYCHIATRIC-SYMPTOMS-
dc.subject.keywordPlusCLINICAL CHARACTERISTICS-
dc.subject.keywordPlusPSYCHOLOGICAL SYMPTOMS-
dc.subject.keywordPlusBEHAVIORAL SYMPTOMS-
dc.subject.keywordPlusNURSING-HOMES-
dc.subject.keywordPlusFOLLOW-UP-
dc.subject.keywordPlusDEMENTIA-
dc.subject.keywordPlusRISK-
dc.subject.keywordAuthorAlzheimer's disease-
dc.subject.keywordAuthordepression-
dc.subject.keywordAuthordisease progression-
dc.subject.keywordAuthorearly-onset-
dc.subject.keywordAuthorgeriatric depression scale-
dc.subject.keywordAuthorprediction-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Neurology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE