Clinical Outcome and Predictive Factors in the Response to Splenectomy in Elderly Patients with Primary Immune Thrombocytopenia: A Multicenter Retrospective Study
DC Field | Value | Language |
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dc.contributor.author | Park, Young Hoon | - |
dc.contributor.author | Yi, Hyeon Gyu | - |
dc.contributor.author | Kim, Chul Soo | - |
dc.contributor.author | Hong, Junshik | - |
dc.contributor.author | Park, Jinny | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.contributor.author | Kim, Ho Young | - |
dc.contributor.author | Kim, Hyo Jung | - |
dc.contributor.author | Zang, Dae Young | - |
dc.contributor.author | Kim, Se Hyung | - |
dc.contributor.author | Park, Seong Kyu | - |
dc.contributor.author | Hong, Dae Sik | - |
dc.contributor.author | Lee, Guk Jin | - |
dc.contributor.author | Jin, Jong-Youl | - |
dc.date.accessioned | 2021-08-11T19:23:59Z | - |
dc.date.available | 2021-08-11T19:23:59Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0001-5792 | - |
dc.identifier.issn | 1421-9662 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/9956 | - |
dc.description.abstract | Background: Because many physicians seem reluctant to recommend splenectomy for elderly patients with immune thrombocytopenia (ITP), we investigated the safety and efficacy of splenectomy and the predictive factors for response in these patients. Methods: 184 patients with primary ITP were retrospectively analyzed based on age at splenectomy: an elderly group (>= 60 years, n = 52) and a younger group (<60 years, n = 132). Results: There was no difference in the response rate of elderly versus younger patients (80.7 vs. 80.3%, p = 0.466). Relapse (45.2 vs. 22.6%, p = 0.006), complications, and median postoperative stay (9.5 vs. 7 days, p = 0.019) were significantly higher in the elderly group. The 5-year relapse-free survival of responders was 51.8% in the elderly group and 76.3% in the younger group (p = 0.002). Response to any treatment before splenectomy (HR 2.9, 95% CI: 1.24-6.80, p = 0.014) and platelet count on postoperative day 14 >= 200 x 10(9)/I (HR 31.43, 95% CI: 4.15-238.28, p = 0.001) were independent factors for a favorable response. Conclusions: Age >= 60 years did not influence the response to splenectomy but was associated with increased relapse and postoperative complications. Splenectomy could provide a durable long-term response for elderly ITP patients. (C) 2016 S. Karger AG, Basel | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | S. Karger AG | - |
dc.title | Clinical Outcome and Predictive Factors in the Response to Splenectomy in Elderly Patients with Primary Immune Thrombocytopenia: A Multicenter Retrospective Study | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.1159/000442703 | - |
dc.identifier.scopusid | 2-s2.0-84955615140 | - |
dc.identifier.wosid | 000372389500006 | - |
dc.identifier.bibliographicCitation | Acta Haematologica, v.135, no.3, pp 162 - 171 | - |
dc.citation.title | Acta Haematologica | - |
dc.citation.volume | 135 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 162 | - |
dc.citation.endPage | 171 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.subject.keywordPlus | SUCCESSFUL LAPAROSCOPIC SPLENECTOMY | - |
dc.subject.keywordPlus | INTERNATIONAL WORKING GROUP | - |
dc.subject.keywordPlus | LONG-TERM RESPONSE | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | PURPURA | - |
dc.subject.keywordPlus | ITP | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordAuthor | Immune thrombocytopenia | - |
dc.subject.keywordAuthor | Splenectomy | - |
dc.subject.keywordAuthor | Response | - |
dc.subject.keywordAuthor | Predictive factor | - |
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