Chemical-induced formation of BZ-junction with base extrusion
DC Field | Value | Language |
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dc.contributor.author | Subramani, VK[Subramani, Vinod Kumar] | - |
dc.contributor.author | Ravichandran, S[Ravichandran, Subramaniyam] | - |
dc.contributor.author | Bansal, V[Bansal, Varun] | - |
dc.contributor.author | Kim, KK[Kim, Kyeong Kyu] | - |
dc.date.accessioned | 2021-07-28T21:25:41Z | - |
dc.date.available | 2021-07-28T21:25:41Z | - |
dc.date.created | 2019-11-28 | - |
dc.date.issued | 2019-01-22 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/11294 | - |
dc.description.abstract | The crystal structure of BZ junction reveals that left-handed Z-DNA stabilized by Z-DNA binding domain (Z alpha) is continuously stacked to right-handed B-DNA with AT bases' extrusion in the junction site. However, this structure might not fully represent the BZ-junction in solution due to the possibility of the junction formation either by crystal packing or Z alpha interaction. Therefore, we investigated BZ-junction in solution with chemical Z-DNA inducers using CD and 2-aminopurine base-extrusion assay. We confirmed the formation of Z-DNA and BZ-junction with base-extrusion by chemical Z-DNA inducers. However, neither typical Z-DNA nor base-extrusion could be detected with some inducers such as spermine, suggesting that the energy barrier for the formation of the BZ junction might vary depending on the Z-DNA induction conditions. (C) 2018 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | Z-DNA | - |
dc.subject | CIRCULAR-DICHROISM | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | HANDED FORMS | - |
dc.subject | Z TRANSITION | - |
dc.subject | BINDING | - |
dc.subject | REVEALS | - |
dc.subject | PROTEIN | - |
dc.title | Chemical-induced formation of BZ-junction with base extrusion | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Subramani, VK[Subramani, Vinod Kumar] | - |
dc.contributor.affiliatedAuthor | Kim, KK[Kim, Kyeong Kyu] | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.12.045 | - |
dc.identifier.scopusid | 2-s2.0-85058384298 | - |
dc.identifier.wosid | 000456491900036 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.508, no.4, pp.1215 - 1220 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 508 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1215 | - |
dc.citation.endPage | 1220 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | Z-DNA | - |
dc.subject.keywordPlus | CIRCULAR-DICHROISM | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | HANDED FORMS | - |
dc.subject.keywordPlus | Z TRANSITION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | Z-DNA | - |
dc.subject.keywordAuthor | BZ-Junction | - |
dc.subject.keywordAuthor | Z-DNA junction | - |
dc.subject.keywordAuthor | 2-Aminopurine | - |
dc.subject.keywordAuthor | Base-extrusion | - |
dc.subject.keywordAuthor | Z-inducer | - |
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