Evodiamine Reduces Caffeine-Induced Sleep Disturbances and Excitation in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ko, YH[Ko, Yong-Hyun] | - |
dc.contributor.author | Shim, KY[Shim, Kyu-Yvon] | - |
dc.contributor.author | Lee, SY[Lee, Seok-Yong] | - |
dc.contributor.author | Jang, CG[Jang, Choon-Gon] | - |
dc.date.accessioned | 2021-07-29T11:25:25Z | - |
dc.date.available | 2021-07-29T11:25:25Z | - |
dc.date.created | 2018-12-18 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/18781 | - |
dc.description.abstract | Worldwide, caffeine is among the most commonly used stimulatory substances. Unfortunately, significant caffeine consumption is associated with several adverse effects, ranging from sleep disturbances (including insomnia) to cardiovascular problems. This study investigates whether treatment with the Evodia rutaecarpa aqueous extract (ERAE) from berries and its major molecular component, evodiamine, can reduce the adverse caffeine-induced sleep-related and excitation effects. We combined measurements from the pentobarbital-induced sleep test, the open field test, and the locomotor activity test in mice that had been dosed with caffeine. We found that ERAE and evodiamine administration reduced the degree of caffeine-induced sleep disruption during the sleep test. Additionally, we found that evodiamine significantly inhibits caffeine-induced excitation during the open field test, as well as decreasing hyperlocomotion in the locomotor activity test. Additional in vitro experiments showed that caffeine administration decreased the expression of gamma-aminobutyric acid (GABA)(A) receptor subunits in the mouse hypothalamus. However, evodiamine treatment significantly reversed this expression reduction. Taken together, our results demonstrate that ERAE and its major compound, evodiamine, provide an excellent candidate for the treatment or prevention of caffeine-induced sleep disturbances and excitatory states, and that the mechanism of these beneficial effects acts, at least in part, through the GABA(A)-ergic system. | - |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | - |
dc.subject | INDUCED LOCOMOTOR-ACTIVITY | - |
dc.subject | NUCLEUS-ACCUMBENS | - |
dc.subject | NERVOUS-SYSTEM | - |
dc.subject | OPEN-FIELD | - |
dc.subject | RECEPTOR | - |
dc.subject | RATS | - |
dc.subject | GABA | - |
dc.subject | BEHAVIORS | - |
dc.subject | ANXIETY | - |
dc.subject | INVOLVEMENT | - |
dc.title | Evodiamine Reduces Caffeine-Induced Sleep Disturbances and Excitation in Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, YH[Ko, Yong-Hyun] | - |
dc.contributor.affiliatedAuthor | Shim, KY[Shim, Kyu-Yvon] | - |
dc.contributor.affiliatedAuthor | Lee, SY[Lee, Seok-Yong] | - |
dc.contributor.affiliatedAuthor | Jang, CG[Jang, Choon-Gon] | - |
dc.identifier.doi | 10.4062/biomolther.2017.146 | - |
dc.identifier.scopusid | 2-s2.0-85053707230 | - |
dc.identifier.wosid | 000444642300002 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, v.26, no.5, pp.432 - 438 | - |
dc.relation.isPartOf | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.title | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.volume | 26 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 432 | - |
dc.citation.endPage | 438 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002375918 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | INDUCED LOCOMOTOR-ACTIVITY | - |
dc.subject.keywordPlus | NUCLEUS-ACCUMBENS | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | OPEN-FIELD | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | GABA | - |
dc.subject.keywordPlus | BEHAVIORS | - |
dc.subject.keywordPlus | ANXIETY | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordAuthor | Evodiamine | - |
dc.subject.keywordAuthor | Evodia rutaecarpa | - |
dc.subject.keywordAuthor | Caffeine | - |
dc.subject.keywordAuthor | gamma-aminobutyric acid receptor | - |
dc.subject.keywordAuthor | Sleep | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(03063) 25-2, SUNGKYUNKWAN-RO, JONGNO-GU, SEOUL, KOREAsamsunglib@skku.edu
COPYRIGHT © 2021 SUNGKYUNKWAN UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.