Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Delivery
DC Field | Value | Language |
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dc.contributor.author | Khatoon, S.[Khatoon, S.] | - |
dc.contributor.author | Han, H.S.[Han, H.S.] | - |
dc.contributor.author | Jeon, J.[Jeon, J.] | - |
dc.contributor.author | Rao, N.V.[Rao, N.V.] | - |
dc.contributor.author | Jeong, D.-W.[Jeong, D.-W.] | - |
dc.contributor.author | Ikram, M.[Ikram, M.] | - |
dc.contributor.author | Yasin, T.[Yasin, T.] | - |
dc.contributor.author | Yi, G.-R.[Yi, G.-R.] | - |
dc.contributor.author | Park, J.H.[Park, J.H.] | - |
dc.date.accessioned | 2021-07-29T14:46:44Z | - |
dc.date.available | 2021-07-29T14:46:44Z | - |
dc.date.created | 2018-05-21 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 2073-4360 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/20482 | - |
dc.description.abstract | Hypoxia, or low oxygen tension, is a common feature of solid tumors. Here, we report hypoxia-responsive mesoporous silica nanoparticles (HR-MSNs) with a 4-nitroimidazole-beta-cyclodextrin (NI-CD) complex that is acting as the hypoxia-responsive gatekeeper. When these CD-HR-MSNs encountered a hypoxic environment, the nitroimidazole (NI) gatekeeper portion of CD-HR-MSNs disintegrated through bioreduction of the hydrophobic NI state to the hydrophilic NI state. Under hypoxic conditions, the release rate of doxorubicin (DOX) from DOX-loaded CD-HR-MSNs (DOX-CD-HR-MSNs) increased along with the disintegration of the gatekeeper. Conversely, DOX release was retarded under normoxic conditions. In vitro experiments confirmed that DOX-CD-HR-MSNs exhibit higher toxicity to hypoxic cells when compared to normoxic cells. Confocal microscopy images indicated that DOX-CD-HR-MSNs effectively release DOX into SCC-7 cells under hypoxic conditions. These results demonstrate that CD-HR-MSNs can release drugs in a hypoxia-responsive manner, and thus are promising drug carriers for hypoxia-targeted cancer therapy. | - |
dc.publisher | MDPI | - |
dc.subject | INORGANIC HYBRID MATERIALS | - |
dc.subject | TARGETED DRUG-DELIVERY | - |
dc.subject | SILICA NANOPARTICLES | - |
dc.subject | CANCER-THERAPY | - |
dc.subject | IN-VIVO | - |
dc.subject | THERANOSTIC PLATFORM | - |
dc.subject | CONTROLLED-RELEASE | - |
dc.subject | TUMOR HYPOXIA | - |
dc.subject | GATEKEEPER | - |
dc.subject | OXYGEN | - |
dc.title | Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Delivery | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Khatoon, S.[Khatoon, S.] | - |
dc.contributor.affiliatedAuthor | Han, H.S.[Han, H.S.] | - |
dc.contributor.affiliatedAuthor | Jeon, J.[Jeon, J.] | - |
dc.contributor.affiliatedAuthor | Rao, N.V.[Rao, N.V.] | - |
dc.contributor.affiliatedAuthor | Jeong, D.-W.[Jeong, D.-W.] | - |
dc.contributor.affiliatedAuthor | Yi, G.-R.[Yi, G.-R.] | - |
dc.contributor.affiliatedAuthor | Park, J.H.[Park, J.H.] | - |
dc.identifier.doi | 10.3390/polym10040390 | - |
dc.identifier.scopusid | 2-s2.0-85044827853 | - |
dc.identifier.wosid | 000435087400048 | - |
dc.identifier.bibliographicCitation | POLYMERS, v.10, no.4 | - |
dc.relation.isPartOf | POLYMERS | - |
dc.citation.title | POLYMERS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | INORGANIC HYBRID MATERIALS | - |
dc.subject.keywordPlus | TARGETED DRUG-DELIVERY | - |
dc.subject.keywordPlus | SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | THERANOSTIC PLATFORM | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | TUMOR HYPOXIA | - |
dc.subject.keywordPlus | GATEKEEPER | - |
dc.subject.keywordPlus | OXYGEN | - |
dc.subject.keywordAuthor | Doxorubicin | - |
dc.subject.keywordAuthor | Hypoxia | - |
dc.subject.keywordAuthor | Mesoporous silica nanoparticles | - |
dc.subject.keywordAuthor | Nitroimidazole | - |
dc.subject.keywordAuthor | β-cyclodextrin | - |
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