ROS-responsive mesoporous silica nanoparticles for MR imaging-guided photodynamically maneuvered chemotherapy
DC Field | Value | Language |
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dc.contributor.author | Vijayakameswara Rao, N.[Vijayakameswara Rao, N.] | - |
dc.contributor.author | Han, H.S.[Han, H.S.] | - |
dc.contributor.author | Lee, H.[Lee, H.] | - |
dc.contributor.author | Nguyen, V.Q.[Nguyen, V.Q.] | - |
dc.contributor.author | Jeon, S.[Jeon, S.] | - |
dc.contributor.author | Jung, D.-W.[Jung, D.-W.] | - |
dc.contributor.author | Lee, J.[Lee, J.] | - |
dc.contributor.author | Yi, G.-R.[Yi, G.-R.] | - |
dc.contributor.author | Park, J.H.[Park, J.H.] | - |
dc.date.accessioned | 2021-07-29T23:46:19Z | - |
dc.date.available | 2021-07-29T23:46:19Z | - |
dc.date.created | 2019-01-07 | - |
dc.date.issued | 2018-05-28 | - |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/24352 | - |
dc.description.abstract | Mesoporous silica nanoparticles (MSNs) with stimuli-responsive gatekeepers have been extensively investigated for controlled drug delivery at the target sites. Herein, we developed reactive oxygen species (ROS)-responsive MSNs (R-MSNs), consisting of a gadolinium (Gd)-DOTA complex as the ROS-responsive gatekeeper and polyethylene glycol (PEG)-conjugated chlorin e6 as the ROS generator, for magnetic resonance (MR) imaging-guided photodynamic chemotherapy. Doxorubicin (DOX), chosen as an anticancer drug, was physically encapsulated into DOTA-conjugated MSNs, followed by chemical crosslinking via the addition of GdCl3. DOX-R-MSNs could effectively maintain their structural integrity in a physiological environment for 7 days and show an enhanced in vitro T1-MR imaging signal for the Gd-DOTA complex. Upon 660 nm laser irradiation, the release rate of DOX from DOX-R-MSNs remarkably increased along with the disintegration of the gatekeeper, whereas DOX release was significantly retarded without irradiation. When DOX-R-MSNs were intravenously injected into tumor-bearing mice, they were effectively accumulated in tumor tissue, which was demonstrated using MR imaging. In addition, tumor growth was significantly suppressed by DOX-R-MSNs, allowing for site-specific release of DOX in a photodynamically maneuvered manner. Overall, these results suggest that R-MSNs have potential as drug carriers for MR imaging-guided photodynamic chemotherapy. © 2018 The Royal Society of Chemistry. | - |
dc.publisher | Royal Society of Chemistry | - |
dc.subject | Chemotherapy | - |
dc.subject | Crosslinking | - |
dc.subject | Gadolinium compounds | - |
dc.subject | Irradiation | - |
dc.subject | Magnetic resonance | - |
dc.subject | Magnetic resonance imaging | - |
dc.subject | Silica nanoparticles | - |
dc.subject | Targeted drug delivery | - |
dc.subject | Tumors | - |
dc.subject | Anticancer drug | - |
dc.subject | Chemical cross-linking | - |
dc.subject | Mesoporous silica nanoparticles | - |
dc.subject | Physiological environment | - |
dc.subject | Reactive oxygen species | - |
dc.subject | Site-specific | - |
dc.subject | Stimuli-responsive | - |
dc.subject | Tumor tissues | - |
dc.subject | Controlled drug delivery | - |
dc.title | ROS-responsive mesoporous silica nanoparticles for MR imaging-guided photodynamically maneuvered chemotherapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Vijayakameswara Rao, N.[Vijayakameswara Rao, N.] | - |
dc.contributor.affiliatedAuthor | Han, H.S.[Han, H.S.] | - |
dc.contributor.affiliatedAuthor | Lee, H.[Lee, H.] | - |
dc.contributor.affiliatedAuthor | Nguyen, V.Q.[Nguyen, V.Q.] | - |
dc.contributor.affiliatedAuthor | Jeon, S.[Jeon, S.] | - |
dc.contributor.affiliatedAuthor | Jung, D.-W.[Jung, D.-W.] | - |
dc.contributor.affiliatedAuthor | Lee, J.[Lee, J.] | - |
dc.contributor.affiliatedAuthor | Yi, G.-R.[Yi, G.-R.] | - |
dc.contributor.affiliatedAuthor | Park, J.H.[Park, J.H.] | - |
dc.identifier.doi | 10.1039/c8nr00888d | - |
dc.identifier.scopusid | 2-s2.0-85047397998 | - |
dc.identifier.wosid | 000433260300022 | - |
dc.identifier.bibliographicCitation | Nanoscale, v.10, no.20, pp.9616 - 9627 | - |
dc.relation.isPartOf | Nanoscale | - |
dc.citation.title | Nanoscale | - |
dc.citation.volume | 10 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 9616 | - |
dc.citation.endPage | 9627 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.subject.keywordPlus | Chemotherapy | - |
dc.subject.keywordPlus | Crosslinking | - |
dc.subject.keywordPlus | Gadolinium compounds | - |
dc.subject.keywordPlus | Irradiation | - |
dc.subject.keywordPlus | Magnetic resonance | - |
dc.subject.keywordPlus | Magnetic resonance imaging | - |
dc.subject.keywordPlus | Silica nanoparticles | - |
dc.subject.keywordPlus | Targeted drug delivery | - |
dc.subject.keywordPlus | Tumors | - |
dc.subject.keywordPlus | Anticancer drug | - |
dc.subject.keywordPlus | Chemical cross-linking | - |
dc.subject.keywordPlus | Mesoporous silica nanoparticles | - |
dc.subject.keywordPlus | Physiological environment | - |
dc.subject.keywordPlus | Reactive oxygen species | - |
dc.subject.keywordPlus | Site-specific | - |
dc.subject.keywordPlus | Stimuli-responsive | - |
dc.subject.keywordPlus | Tumor tissues | - |
dc.subject.keywordPlus | Controlled drug delivery | - |
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