Current globalization of drug interventional clinical trials: characteristics and associated factors, 2011-2013
DC Field | Value | Language |
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dc.contributor.author | Jeong, S[Jeong, Sohyun] | - |
dc.contributor.author | Sohn, M[Sohn, Minji] | - |
dc.contributor.author | Kim, JH[Kim, Jae Hyun] | - |
dc.contributor.author | Ko, M[Ko, Minoh] | - |
dc.contributor.author | Seo, HW[Seo, Hee-won] | - |
dc.contributor.author | Song, YK[Song, Yun-Kyoung] | - |
dc.contributor.author | Choi, B[Choi, Boyoon] | - |
dc.contributor.author | Han, N[Han, Nayoung] | - |
dc.contributor.author | Na, HS[Na, Han-Sung] | - |
dc.contributor.author | Lee, JG[Lee, Jong Gu] | - |
dc.contributor.author | Kim, IW[Kim, In-Wha] | - |
dc.contributor.author | Oh, JM[Oh, Jung Mi] | - |
dc.contributor.author | Lee, E[Lee, Euni] | - |
dc.date.accessioned | 2021-07-30T09:46:06Z | - |
dc.date.available | 2021-07-30T09:46:06Z | - |
dc.date.created | 2017-08-02 | - |
dc.date.issued | 2017-06-21 | - |
dc.identifier.issn | 1745-6215 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/28542 | - |
dc.description.abstract | Background: Clinical trial globalization is a major trend for industry-sponsored clinical trials. There has been a shift in clinical trial sites towards emerging regions of Eastern Europe, Latin America, Asia, the Middle East, and Africa. Our study objectives were to evaluate the current characteristics of clinical trials and to find out the associated multiple factors which could explain clinical trial globalization and its implications for clinical trial globalization in 2011-2013. Methods: The data elements of "phase," "recruitment status," " type of sponsor," " age groups," and " design of trial" from 30 countries were extracted from the ClinicalTrials. gov website. Ten continental representative countries including the USA were selected and the design elements were compared to those of the USA. Factors associated with trial site distribution were chosen for a multilinear regression analysis. Results: The USA, Germany, France, Canada, and United Kingdom were the " top five" countries which frequently held clinical trials. The design elements from nine continental representative countries were quite different from those of the USA; phase 1 trials were more prevalent in India (OR 1.517, p< 0.001) while phase 3 trials were much more prevalent in all nine representative countries than in the USA. A larger number of " child" age group trials was performed in Poland (OR 1.852, p < 0.001), Israel (OR 1.546, p = 0.005), and South Africa (OR 1.963, p < 0.001) than in the USA. Multivariate analysis showed that health care expenditure per capita, Economic Freedom Index, Human Capital Index, and Intellectual Property Rights Index could explain the variance of regional distribution of clinical trials by 63.6%. Conclusions: The globalization of clinical trials in the emerging regions of Asia, South Africa, and Eastern Europe developed in parallel with the factors of economic drive, population for recruitment, and regulatory constraints. | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.subject | Africa | - |
dc.subject | Article | - |
dc.subject | Asia | - |
dc.subject | Canada | - |
dc.subject | clinical trial (topic) | - |
dc.subject | controlled study | - |
dc.subject | drug interventional clinical trial | - |
dc.subject | Eastern Europe | - |
dc.subject | economic aspect | - |
dc.subject | France | - |
dc.subject | Germany | - |
dc.subject | groups by age | - |
dc.subject | health care cost | - |
dc.subject | human | - |
dc.subject | India | - |
dc.subject | Israel | - |
dc.subject | Middle East | - |
dc.subject | patent | - |
dc.subject | phase 1 clinical trial | - |
dc.subject | phase 3 clinical trial | - |
dc.subject | Poland | - |
dc.subject | prevalence | - |
dc.subject | regression analysis | - |
dc.subject | South Africa | - |
dc.subject | South and Central America | - |
dc.subject | United Kingdom | - |
dc.subject | United States | - |
dc.subject | age | - |
dc.subject | chi square distribution | - |
dc.subject | comparative study | - |
dc.subject | drug cost | - |
dc.subject | drug therapy | - |
dc.subject | economics | - |
dc.subject | financial management | - |
dc.subject | international cooperation | - |
dc.subject | methodology | - |
dc.subject | multicenter study (topic) | - |
dc.subject | multivariate analysis | - |
dc.subject | odds ratio | - |
dc.subject | patient selection | - |
dc.subject | procedures | - |
dc.subject | research subject | - |
dc.subject | statistical model | - |
dc.subject | Age Factors | - |
dc.subject | Chi-Square Distribution | - |
dc.subject | Clinical Trials as Topic | - |
dc.subject | Drug Costs | - |
dc.subject | Drug Therapy | - |
dc.subject | Health Expenditures | - |
dc.subject | Humans | - |
dc.subject | Intellectual Property | - |
dc.subject | International Cooperation | - |
dc.subject | Internationality | - |
dc.subject | Linear Models | - |
dc.subject | Multicenter Studies as Topic | - |
dc.subject | Multivariate Analysis | - |
dc.subject | Odds Ratio | - |
dc.subject | Patient Selection | - |
dc.subject | Research Design | - |
dc.subject | Research Subjects | - |
dc.subject | Research Support as Topic | - |
dc.title | Current globalization of drug interventional clinical trials: characteristics and associated factors, 2011-2013 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeong, S[Jeong, Sohyun] | - |
dc.identifier.doi | 10.1186/s13063-017-2025-1 | - |
dc.identifier.scopusid | 2-s2.0-85021089198 | - |
dc.identifier.wosid | 000403846100001 | - |
dc.identifier.bibliographicCitation | TRIALS, v.18, no.1 | - |
dc.relation.isPartOf | TRIALS | - |
dc.citation.title | TRIALS | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordAuthor | Clinical trials | - |
dc.subject.keywordAuthor | Intellectual property rights index | - |
dc.subject.keywordAuthor | Economic freedom index | - |
dc.subject.keywordAuthor | Human capital index | - |
dc.subject.keywordAuthor | Health care expenditure per capita | - |
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