Risk factors and molecular epidemiology of community-onset, multidrug resistance extended-spectrum beta-lactamase-producing Escherichia coli infections
DC Field | Value | Language |
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dc.contributor.author | Park, SY[Park, So Yeon] | - |
dc.contributor.author | Kang, CI[Kang, Cheol-In] | - |
dc.contributor.author | Wi, YM[Wi, Yu Mi] | - |
dc.contributor.author | Chung, DR[Chung, Doo Ryeon] | - |
dc.contributor.author | Peck, KR[Peck, Kyong Ran] | - |
dc.contributor.author | Lee, NY[Lee, Nam-Yong] | - |
dc.contributor.author | Song, JH[Song, Jae-Hoon] | - |
dc.date.accessioned | 2021-07-30T15:45:48Z | - |
dc.date.available | 2021-07-30T15:45:48Z | - |
dc.date.created | 2021-06-23 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/30557 | - |
dc.description.abstract | Background/Aims: Although multidrug resistance (MDR) among extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) poses significant therapeutic challenges, little is known regarding the risk factors and epidemiology of community-onset MDR-ESBL-EC infections. We performed this study to investigate risk factors and the molecular epidemiology of community-onset MDR-ESBL-EC infections. Methods: We conducted a case-control-control study of community-onset infections. MDR-ESBL-EC was defined as ESBL-EC that demonstrated in vitro resistance to trimethoprim-sulfamethoxazole, fluoroquinolones (FQs), and gentamicin. Patients with MDR-ESBL-EC infections were designated as case patients. A control group I (CG I) patient was defined as a person whose clinical sample yielded ESBL-EC that did not meet the criteria for MDR. A control group II (CG II) patient was defined as a patient with a non-ESBL-EC infection. Results: Of 108 patients with ESBL-EC infections, 30 cases (27.8%) were due to MDR-ESBL-EC. Compared with CG I, prior use of FQs (odds ratio [OR], 3.16; 95% confidence interval [CI], 1.11 to 8.98) and immunosuppressant use (OR, 10.47; 95% CI, 1.07 to 102.57) were significantly associated with MDR-ESBL-EC. Compared with CG II, prior use of FQs (OR, 15.53; 95% CI, 2.86 to 84.27) and healthcare-associated infection (OR, 5.98; 95% CI, 2.26 to 15.86) were significantly associated with MDR-ESBL-EC. CTX-M-15 was the most common in MDR-ESBL-EC infections (59.1% [13/22]), while CTX-M-14 was the most common in non-MDR-ESBL-EC infections (41.6% [32/77]). CTX-M-15 was significantly associated with MDR-ESBL-EC (59.1% vs. 32.5%, p = 0.028). Pulsed-field gel electrophoresis showed clonal diversity of MDR-ESBL-EC isolates. Conclusions: The emergence of strains of MDR-ESBL-EC in the community poses an important new public health threat. More information on the emergence and transmission of these strains will be necessary in order to prevent their spread. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.subject | BLOOD-STREAM INFECTIONS | - |
dc.subject | ANTIMICROBIAL RESISTANCE | - |
dc.subject | BACTEREMIA | - |
dc.subject | ENTEROBACTERIACEAE | - |
dc.subject | GUIDELINES | - |
dc.subject | PYELONEPHRITIS | - |
dc.subject | DEFINITIONS | - |
dc.subject | PSEUDOMONAS | - |
dc.subject | SELECTION | - |
dc.subject | DISEASES | - |
dc.title | Risk factors and molecular epidemiology of community-onset, multidrug resistance extended-spectrum beta-lactamase-producing Escherichia coli infections | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Peck, KR[Peck, Kyong Ran] | - |
dc.identifier.doi | 10.3904/kjim.2015.113 | - |
dc.identifier.scopusid | 2-s2.0-85009476299 | - |
dc.identifier.wosid | 000392223500016 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, v.32, no.1, pp.146 - 157 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.title | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 146 | - |
dc.citation.endPage | 157 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002191634 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | BLOOD-STREAM INFECTIONS | - |
dc.subject.keywordPlus | ANTIMICROBIAL RESISTANCE | - |
dc.subject.keywordPlus | BACTEREMIA | - |
dc.subject.keywordPlus | ENTEROBACTERIACEAE | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | PYELONEPHRITIS | - |
dc.subject.keywordPlus | DEFINITIONS | - |
dc.subject.keywordPlus | PSEUDOMONAS | - |
dc.subject.keywordPlus | SELECTION | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordAuthor | Drug resistance, multiple | - |
dc.subject.keywordAuthor | Extended-spectrum beta-lactamase | - |
dc.subject.keywordAuthor | Escherichia coli | - |
dc.subject.keywordAuthor | Community-onset infection | - |
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