The new stimulant designer compound pentedrone exhibits rewarding properties and affects dopaminergic activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, J.-Y.[Hwang, J.-Y.] | - |
dc.contributor.author | Kim, J.-S.[Kim, J.-S.] | - |
dc.contributor.author | Oh, J.-H.[Oh, J.-H.] | - |
dc.contributor.author | Hong, S.-I.[Hong, S.-I.] | - |
dc.contributor.author | Ma, S.-X.[Ma, S.-X.] | - |
dc.contributor.author | Jung, Y.-H.[Jung, Y.-H.] | - |
dc.contributor.author | Ko, Y.-H.[Ko, Y.-H.] | - |
dc.contributor.author | Lee, S.-Y.[Lee, S.-Y.] | - |
dc.contributor.author | Kim, H.-C.[Kim, H.-C.] | - |
dc.contributor.author | Jang, C.-G.[Jang, C.-G.] | - |
dc.date.accessioned | 2021-07-30T16:25:23Z | - |
dc.date.available | 2021-07-30T16:25:23Z | - |
dc.date.created | 2017-09-06 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1355-6215 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/30662 | - |
dc.description.abstract | Cathinone derivatives are new recreational drugs known to produce psychostimulant effects. However, unlike other psychostimulants, the addictive potential of cathinone derivatives has not been widely studied. Here, we investigated the effects of pentedrone, a type of cathinone derivative, on the dopaminergic system using reverse transcription polymerase chain reaction and Western blot. We also evaluated the addictive potential of pentedrone using conditioned place preference and self-administration. We found that pentedrone increased the mRNA expression of dopamine 1 receptor, dopamine 2 receptor and dopamine transporter, as well as induced phosphorylation of cAMP response element-binding protein in PC-12 cells. Additionally, pentedrone at 3 and 10mg/kg significantly increased conditioned place preference in mice, while pentedrone at 0.3mg/kg/infusion significantly increased self-administration in rats. Finally, we found that acute administration of pentedrone enhanced locomotor activity in a dose-dependent manner. Collectively, these data suggest that the addictive properties of pentedrone may be due to its effects on the dopaminergic system. | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | CONDITIONED PLACE PREFERENCE | - |
dc.subject | BATH SALTS | - |
dc.subject | TRANSCRIPTIONAL RESPONSES | - |
dc.subject | FEMALE RATS | - |
dc.subject | IN-VITRO | - |
dc.subject | MEPHEDRONE | - |
dc.subject | COCAINE | - |
dc.subject | METHAMPHETAMINE | - |
dc.subject | TRANSPORTER | - |
dc.subject | CATHINONES | - |
dc.title | The new stimulant designer compound pentedrone exhibits rewarding properties and affects dopaminergic activity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, J.-Y.[Hwang, J.-Y.] | - |
dc.contributor.affiliatedAuthor | Kim, J.-S.[Kim, J.-S.] | - |
dc.contributor.affiliatedAuthor | Oh, J.-H.[Oh, J.-H.] | - |
dc.contributor.affiliatedAuthor | Hong, S.-I.[Hong, S.-I.] | - |
dc.contributor.affiliatedAuthor | Ma, S.-X.[Ma, S.-X.] | - |
dc.contributor.affiliatedAuthor | Jung, Y.-H.[Jung, Y.-H.] | - |
dc.contributor.affiliatedAuthor | Ko, Y.-H.[Ko, Y.-H.] | - |
dc.contributor.affiliatedAuthor | Lee, S.-Y.[Lee, S.-Y.] | - |
dc.contributor.affiliatedAuthor | Jang, C.-G.[Jang, C.-G.] | - |
dc.identifier.doi | 10.1111/adb.12299 | - |
dc.identifier.scopusid | 2-s2.0-85010338458 | - |
dc.identifier.wosid | 000393902700009 | - |
dc.identifier.bibliographicCitation | ADDICTION BIOLOGY, v.22, no.1, pp.117 - 128 | - |
dc.relation.isPartOf | ADDICTION BIOLOGY | - |
dc.citation.title | ADDICTION BIOLOGY | - |
dc.citation.volume | 22 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 117 | - |
dc.citation.endPage | 128 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Substance Abuse | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Substance Abuse | - |
dc.subject.keywordPlus | CONDITIONED PLACE PREFERENCE | - |
dc.subject.keywordPlus | BATH SALTS | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL RESPONSES | - |
dc.subject.keywordPlus | FEMALE RATS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | MEPHEDRONE | - |
dc.subject.keywordPlus | COCAINE | - |
dc.subject.keywordPlus | METHAMPHETAMINE | - |
dc.subject.keywordPlus | TRANSPORTER | - |
dc.subject.keywordPlus | CATHINONES | - |
dc.subject.keywordAuthor | Cathinone | - |
dc.subject.keywordAuthor | conditioned place preference | - |
dc.subject.keywordAuthor | dopamine | - |
dc.subject.keywordAuthor | pentedrone | - |
dc.subject.keywordAuthor | self-administration | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(03063) 25-2, SUNGKYUNKWAN-RO, JONGNO-GU, SEOUL, KOREAsamsunglib@skku.edu
COPYRIGHT © 2021 SUNGKYUNKWAN UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.