Effect of dipeptidyl peptidase-4 inhibitor on all-cause mortality and coronary revascularization in diabetic patients
DC Field | Value | Language |
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dc.contributor.author | Park H.E.[Park H.E.] | - |
dc.contributor.author | Jeon J.[Jeon J.] | - |
dc.contributor.author | Hwang I.-C.[Hwang I.-C.] | - |
dc.contributor.author | Sung J.[Sung J.] | - |
dc.contributor.author | Lee S.-P.[Lee S.-P.] | - |
dc.contributor.author | Kim H.-K.[Kim H.-K.] | - |
dc.contributor.author | Cho G.-Y.[Cho G.-Y.] | - |
dc.contributor.author | Sohn D.-W.[Sohn D.-W.] | - |
dc.contributor.author | Kim Y.-J.[Kim Y.-J.] | - |
dc.date.accessioned | 2021-08-01T23:25:47Z | - |
dc.date.available | 2021-08-01T23:25:47Z | - |
dc.date.created | 2016-08-07 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1975-4612 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/42095 | - |
dc.description.abstract | Background: Anti-atherosclerotic effect of dipeptidyl peptidase-4 (DPP-4) inhibitors has been suggested from previous studies, and yet, its association with cardiovascular outcome has not been demonstrated. We aimed to evaluate the effect of DPP-4 inhibitors in reducing mortality and coronary revascularization, in association with baseline coronary computed tomography (CT). Methods: The current study was performed as a multi-center, retrospective observational cohort study. All subjects with diabetes mellitus who had diagnostic CT during 2007–2011 were included, and 1866 DPP-4 inhibitor users and 5179 non-users were compared for outcome. The primary outcome was all-cause mortality and secondary outcome included any coronary revascularization therapy after 90 days of CT in addition to all-cause mortality. Results: DPP-4 inhibitors users had significantly less adverse events [0.8% vs. 4.4% in users vs. non-users, adjusted hazard ratios (HR) 0.220, 95% confidence interval (CI) 0.102–0.474, p = 0.0001 for primary outcome, 4.1% vs. 7.6% in users vs. non-users, HR 0.517, 95% CI 0.363–0.735, p = 0.0002 for secondary outcome, adjusted variables were age, sex, presence of hypertension, high sensitivity C-reactive protein, glycated hemoglobin, statin use, coronary artery calcium score and degree of stenosis]. Interestingly, DPP-4 inhibitor seemed to be beneficial only in subjects without significant stenosis (adjusted HR 0.148, p = 0.0013 and adjusted HR 0.525, p = 0.0081 for primary and secondary outcome). Conclusion: DPP-4 inhibitor is associated with reduced all-cause mortality and coronary revascularization in diabetic patients. Such beneficial effect was significant only in those without significant coronary stenosis, which implies that DPP-4 inhibitor may have beneficial effect in earlier stage of atherosclerosis. © 2015 Korean Society of Echocardiography. | - |
dc.publisher | 한국심초음파학회 | - |
dc.title | Effect of dipeptidyl peptidase-4 inhibitor on all-cause mortality and coronary revascularization in diabetic patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeon J.[Jeon J.] | - |
dc.contributor.affiliatedAuthor | Sung J.[Sung J.] | - |
dc.identifier.doi | 10.4250/jcu.2015.23.4.233 | - |
dc.identifier.scopusid | 2-s2.0-84954433468 | - |
dc.identifier.bibliographicCitation | Journal of Cardiovascular Ultrasound, v.23, no.4, pp.233 - 243 | - |
dc.relation.isPartOf | Journal of Cardiovascular Ultrasound | - |
dc.citation.title | Journal of Cardiovascular Ultrasound | - |
dc.citation.volume | 23 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 233 | - |
dc.citation.endPage | 243 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002059624 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Cardiovascular outcome | - |
dc.subject.keywordAuthor | Computed tomography | - |
dc.subject.keywordAuthor | Dipeptidyl peptidase-4 inhibitor | - |
dc.subject.keywordAuthor | Mortality | - |
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