Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features
DC Field | Value | Language |
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dc.contributor.author | Ahn S.[Ahn S.] | - |
dc.contributor.author | Kwon G.Y.[Kwon G.Y.] | - |
dc.contributor.author | Cho Y.M.[Cho Y.M.] | - |
dc.contributor.author | Jun S.-Y.[Jun S.-Y.] | - |
dc.contributor.author | Choi C.[Choi C.] | - |
dc.contributor.author | Kim H.-J.[Kim H.-J.] | - |
dc.contributor.author | Park Y.W.[Park Y.W.] | - |
dc.contributor.author | Park W.S.[Park W.S.] | - |
dc.contributor.author | Shim J.W.[Shim J.W.] | - |
dc.date.accessioned | 2021-08-04T09:52:32Z | - |
dc.date.available | 2021-08-04T09:52:32Z | - |
dc.date.created | 2016-08-06 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 1860-1480 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/58341 | - |
dc.description.abstract | Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is a subtype of renal cell carcinoma (RCC) with unique morphologic features found exclusively in the background of end-stage renal disease. We analyzed the clinicopathologic features and immumoreactive profiles of 12 cases of ACD-RCC to further characterize this recently recognized entity. Review of histologic slides was performed in conjunction with immunohistochemical staining directed to the contemporary diagnostic antibodies and the putative target therapy-related markers. Histologically, the tumors showed characteristic inter-or intracellular microlumens and eosinophilic tumor cells. Intratumoral hemosiderin deposition and degenerating foamy tumor cells were consistent findings which were not previously described. Immunohistochemically, all the tumors were positive for alpha-methylacyl-CoA-racemase, CD10, pan-cytokeratin, PTEN (phosphatase and tensin homolog deleted on chromosome 10) and c-met, while negative for carbonic anhydrase-9, CD57, CD68, c-kit, pax-2, platelet-derived growth factor receptor (PDGFR)-alpha or vascular endothelial growth factor receptor (VEGFR)-2. Heterogenous staining was found for CK7 and kidney-specific cadherin. Positive reaction to c-met suggests its utility as a plausible therapeutic target in ACD-RCC. Thus, we present the unique morphologic and immunopathologic features of ACD-RCC, which may be helpful in both diagnostic and therapeutic aspects. | - |
dc.publisher | SPRINGER JAPAN KK | - |
dc.subject | CALCIUM-OXALATE DEPOSITION | - |
dc.subject | KIDNEY-DISEASE | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | MET | - |
dc.subject | EXPRESSION | - |
dc.subject | EMPHASIS | - |
dc.subject | HEMOSIDERIN | - |
dc.subject | SUNITINIB | - |
dc.subject | THERAPY | - |
dc.subject | PATHWAY | - |
dc.title | Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn S.[Ahn S.] | - |
dc.contributor.affiliatedAuthor | Kwon G.Y.[Kwon G.Y.] | - |
dc.identifier.doi | 10.1007/s00795-013-0028-x | - |
dc.identifier.scopusid | 2-s2.0-84891487848 | - |
dc.identifier.wosid | 000328262200007 | - |
dc.identifier.bibliographicCitation | MEDICAL MOLECULAR MORPHOLOGY, v.46, no.4, pp.225 - 232 | - |
dc.relation.isPartOf | MEDICAL MOLECULAR MORPHOLOGY | - |
dc.citation.title | MEDICAL MOLECULAR MORPHOLOGY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 225 | - |
dc.citation.endPage | 232 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Microscopy | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Microscopy | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordAuthor | Acquired cystic disease | - |
dc.subject.keywordAuthor | c-met | - |
dc.subject.keywordAuthor | Renal cell carcinoma | - |
dc.subject.keywordAuthor | Target therapy | - |
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