T-lymphocyte CREB as a potential biomarker of response to antidepressant drugs
DC Field | Value | Language |
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dc.contributor.author | Lim, SW[Lim, Shinn-Won] | - |
dc.contributor.author | Kim, S[Kim, Seonwoo] | - |
dc.contributor.author | Carroll, BJ[Carroll, Bernard J.] | - |
dc.contributor.author | Kim, DK[Kim, Doh Kwan] | - |
dc.date.accessioned | 2021-08-04T16:57:21Z | - |
dc.date.available | 2021-08-04T16:57:21Z | - |
dc.date.created | 2016-08-06 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 1461-1457 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/60402 | - |
dc.description.abstract | Response to drug treatment of major depression is variable and biomarkers of response are needed. Cyclic AMP response element binding protein (CREB) is considered a key mediator of antidepressant drug effect. We studied CREB in T-lymphocytes as a potential predictor of response to a selective serotonin reuptake inhibitor (SSRI) in 69 Korean depressed patients. We determined total CREB (tCREB), phosphorylated CREB (pCREB) and CRE-DNA binding using immunoblot and electrophoretic mobility shift assays, at baseline and after 6 wk treatment. Thirty-four healthy controls were also studied. The rate of response was 36 of 69 cases (52%). Baseline levels of tCREB and pCREB were lower in the total depressed group compared to controls (p = 0.044 and p < 0.001, respectively). Baseline tCREB values in responders were significantly reduced in comparison to non-responders and to controls. After 6 wk treatment, median values of change of all CREB measures were greater in responders (36) than in non-responders (33; p < 0.001 for tCREB, p = 0.003 for pCREB, and p = 0.072 for CRE-DNA binding). Similar but less robust changes in CREB variables distinguished remitters from non-remitters. The optimum value of baseline tCREB predicted response with a positive predicted value of 0.778 [21/27; 95% confidence intervals (CI) 0.621-0.935], negative predictive value of 0.643 (27/42; 95% CI 0.498-0.788) and accuracy of 0.695 (48/69; 95% CI 0.586-0.804). Patients with low baseline tCREB had a significantly greater rate of response (78%) than patients with high baseline tCREB (36%), p < 0.001. Moreover, the greatest changes in tCREB with treatment were observed in subjects who did respond. This preliminary study suggests that T-lymphocytic CREB biomarkers are reduced in depressed patients and may assist in the prediction of response to SSRI drugs in depression. | - |
dc.publisher | CAMBRIDGE UNIV PRESS | - |
dc.subject | ELEMENT-BINDING PROTEIN | - |
dc.subject | PERIPHERAL-BLOOD LYMPHOCY | - |
dc.title | T-lymphocyte CREB as a potential biomarker of response to antidepressant drugs | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, DK[Kim, Doh Kwan] | - |
dc.identifier.doi | 10.1017/S1461145712001125 | - |
dc.identifier.scopusid | 2-s2.0-84877991719 | - |
dc.identifier.wosid | 000319127100004 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, v.16, no.5, pp.967 - 974 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | - |
dc.citation.volume | 16 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 967 | - |
dc.citation.endPage | 974 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ELEMENT-BINDING PROTEIN | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD LYMPHOCY | - |
dc.subject.keywordAuthor | Antidepressant | - |
dc.subject.keywordAuthor | biomarker | - |
dc.subject.keywordAuthor | CREB | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | perip | - |
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