Serologic Evaluation of Healthcare Workers Caring for COVID-19 Patients in the Republic of Korea
DC Field | Value | Language |
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dc.contributor.author | Ko, J.-H.[Ko, J.-H.] | - |
dc.contributor.author | Lee, J.Y.[Lee, J.Y.] | - |
dc.contributor.author | Kim, H.A.[Kim, H.A.] | - |
dc.contributor.author | Kang, S.-J.[Kang, S.-J.] | - |
dc.contributor.author | Baek, J.Y.[Baek, J.Y.] | - |
dc.contributor.author | Park, S.-J.[Park, S.-J.] | - |
dc.contributor.author | Hyun, M.[Hyun, M.] | - |
dc.contributor.author | Jo, I.J.[Jo, I.J.] | - |
dc.contributor.author | Chung, C.R.[Chung, C.R.] | - |
dc.contributor.author | Kim, Y.-J.[Kim, Y.-J.] | - |
dc.contributor.author | Kang, E.-S.[Kang, E.-S.] | - |
dc.contributor.author | Choi, Y.K.[Choi, Y.K.] | - |
dc.contributor.author | Chang, H.-H.[Chang, H.-H.] | - |
dc.contributor.author | Jung, S.I.[Jung, S.I.] | - |
dc.contributor.author | Peck, K.R.[Peck, K.R.] | - |
dc.date.accessioned | 2021-07-28T13:08:08Z | - |
dc.date.available | 2021-07-28T13:08:08Z | - |
dc.date.created | 2021-06-22 | - |
dc.date.issued | 2020-11-20 | - |
dc.identifier.issn | 1664-302X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/6414 | - |
dc.description.abstract | The safety of healthcare workers (HCWs) against severe acute respiratory syndrome virus 2 (SARS-CoV-2) transmission is an important aspect of managing the coronavirus disease 2019 (COVID-19) pandemic. In the South Korea, highly stringent infection prevention and control (IPC) guidelines are implemented, and reports of healthcare-associated SARS-CoV-2 transmission among HCWs are limited. However, subclinical infections may have been missed by the current symptom-based screening strategy. To evaluate the risk of undetected SARS-CoV-2 transmissions from COVID-19 patients to HCWs, we conducted a multicenter seroprevalence study after the first surge of the COVID-19 outbreak. A total of 432 HCWs were evaluated, comprising 309 HCWs designated to laboratory-confirmed COVID-19 patient care and 123 non-designated HCWs. Designated HCWs wore personal protective equipment including an N95 respirator, eye protection, hooded overalls, shoe covers, and inner and outer gloves. Use of a powered air-purifying respirator was recommended for aerosol-generating procedures or long-duration care activities. A high-sensitivity (99.1%) fluorescence immunoassay immunoglobulin G (IgG) kit was used as the initial screening test, and two enzyme-linked immunosorbent assay kits for total and IgG antibodies were used to confirm the test results. A microneutralization test was additionally performed to evaluate the neutralizing activity of positive specimens. Among the evaluated HCWs, none of the non-designated HCWs had a positive result, while one of the HCWs designated for COVID-19 patient care (1/309, 0.3%) was seropositive for SARS-CoV-2 with confirmed neutralizing activity (1:40). This finding suggests that subclinical seroconversion may occur among HCWs caring for COVID-19 patients, although the risk is low under strict IPC guidance. © Copyright © 2020 Ko, Lee, Kim, Kang, Baek, Park, Hyun, Jo, Chung, Kim, Kang, Choi, Chang, Jung and Peck. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Serologic Evaluation of Healthcare Workers Caring for COVID-19 Patients in the Republic of Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, J.-H.[Ko, J.-H.] | - |
dc.contributor.affiliatedAuthor | Jo, I.J.[Jo, I.J.] | - |
dc.contributor.affiliatedAuthor | Chung, C.R.[Chung, C.R.] | - |
dc.contributor.affiliatedAuthor | Kim, Y.-J.[Kim, Y.-J.] | - |
dc.contributor.affiliatedAuthor | Kang, E.-S.[Kang, E.-S.] | - |
dc.contributor.affiliatedAuthor | Peck, K.R.[Peck, K.R.] | - |
dc.identifier.doi | 10.3389/fmicb.2020.587613 | - |
dc.identifier.scopusid | 2-s2.0-85097219670 | - |
dc.identifier.wosid | 000595387100001 | - |
dc.identifier.bibliographicCitation | Frontiers in Microbiology, v.11 | - |
dc.relation.isPartOf | Frontiers in Microbiology | - |
dc.citation.title | Frontiers in Microbiology | - |
dc.citation.volume | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | EAST RESPIRATORY SYNDROME | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordAuthor | antibody | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | healthcare worker | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | serology | - |
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