Effect of particle size on the dissolution behaviors of poorly water-soluble drugs
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chu, KR[Chu, Kyung Rok] | - |
dc.contributor.author | Lee, E[Lee, Eunhee] | - |
dc.contributor.author | Jeong, SH[Jeong, Seong Hoon] | - |
dc.contributor.author | Park, ES[Park, Eun-Seok] | - |
dc.date.accessioned | 2021-08-05T07:55:04Z | - |
dc.date.available | 2021-08-05T07:55:04Z | - |
dc.date.created | 2016-08-06 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/64988 | - |
dc.description.abstract | This study examined the effects of the particle size of various poorly water-soluble drugs on their dissolution behavior through physicochemical and mathematical analysis. As model drugs, hydrochlorothiazide, aceclofenac, ibuprofen and a discovery candidate were selected. The materials were crystallized using an evaporation method and milled without transformation behavior of crystal forms. The particles were sieved and divided into four size groups (< 45 mu m, 45 similar to 150 mu m, 150 similar to 250 mu m, and 250 similar to 600 mu m). The specific surface area with regard to the particle size was measured using a BET surface area measurement. The specific surface area increased with decreasing particle size of the drug, resulting in an increase in dissolution rate. During the initial period of the dissolution study, significant differences in dissolution rate were observed according to the particle size and specific surface areas. On the other hand, in the later stages, the surface-specific dissolution rate was almost consistent regardless of the particle size. These observations were evaluated mathematically and the results suggested that the dissolution rate of poorly soluble drugs is strongly related to the particle size distribution. Moreover, physicochemical analysis helped explain the effect of particle size on the dissolution profiles. | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.subject | SURFACE | - |
dc.subject | BIOAVAILABILITY | - |
dc.subject | AGITATION | - |
dc.subject | POWDERS | - |
dc.title | Effect of particle size on the dissolution behaviors of poorly water-soluble drugs | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, ES[Park, Eun-Seok] | - |
dc.identifier.doi | 10.1007/s12272-012-0709-3 | - |
dc.identifier.scopusid | 2-s2.0-84864958459 | - |
dc.identifier.wosid | 000307299000010 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.35, no.7, pp.1187 - 1195 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 35 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1187 | - |
dc.citation.endPage | 1195 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordPlus | AGITATION | - |
dc.subject.keywordPlus | POWDERS | - |
dc.subject.keywordAuthor | Particle size | - |
dc.subject.keywordAuthor | Dissolution | - |
dc.subject.keywordAuthor | Poorly water soluble d | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(03063) 25-2, SUNGKYUNKWAN-RO, JONGNO-GU, SEOUL, KOREAsamsunglib@skku.edu
COPYRIGHT © 2021 SUNGKYUNKWAN UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.