Relation of Ruptured Plaque Culprit Lesion Phenotype and Outcomes in Patients With ST Elevation Acute Myocardial Infarction
DC Field | Value | Language |
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dc.contributor.author | Kim, SW[Kim, Sang Wook] | - |
dc.contributor.author | Hong, YJ[Hong, Young Joon] | - |
dc.contributor.author | Mintz, GS[Mintz, Gary S.] | - |
dc.contributor.author | Lee, SY[Lee, Sung Yun] | - |
dc.contributor.author | Doh, JH[Doh, Jun Hyung] | - |
dc.contributor.author | Lim, SH[Lim, Seong Hoon] | - |
dc.contributor.author | Kang, HJ[Kang, Hyun Jae] | - |
dc.contributor.author | Rha, SW[Rha, Seung Woon] | - |
dc.contributor.author | Kim, JS[Kim, Jung Sun] | - |
dc.contributor.author | Lee, WS[Lee, Wang-Soo] | - |
dc.contributor.author | Oh, SJ[Oh, Seong Jin] | - |
dc.contributor.author | Lee, S[Lee, Sahng] | - |
dc.contributor.author | Hahn, JY[Hahn, Joo Yong] | - |
dc.contributor.author | Lee, JB[Lee, Jin Bae] | - |
dc.contributor.author | Bae, JH[Bae, Jang Ho] | - |
dc.contributor.author | Hur, SH[Hur, Seung Ho] | - |
dc.contributor.author | Han, SH[Han, Seung Hwan] | - |
dc.contributor.author | Jeong, MH[Jeong, Myung Ho] | - |
dc.contributor.author | Kim, YJ[Kim, Young Jo] | - |
dc.date.accessioned | 2021-08-05T11:51:17Z | - |
dc.date.available | 2021-08-05T11:51:17Z | - |
dc.date.created | 2016-08-06 | - |
dc.date.issued | 2012-03-15 | - |
dc.identifier.issn | 0002-9149 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/66042 | - |
dc.description.abstract | We used virtual histology intravascular ultrasound (VU-IVUS) to assess culprit plaque rupture in 172 patients with ST-segment elevation acute myocardial infarction. VH-IVUS-defined thin-capped fibroatheroma (VH-TCFA) had necrotic core (NC) > 10% of plaque area, plaque burden > 40%, and NC in contact with the lumen for >= 3 image slices. Ruptured plaques were present in 72 patients, 61% of which were located in the proximal 30 mm of a coronary artery. Thirty-five were classified as VH-TCFA and 37 as non-VH-TCFA. Vessel size, lesion length, plaque burden, minimal lumen area, and frequency of positive remodeling were similar in VH-TCFA and non-VH-TCFA. However, the NC areas within the rupture sites of VH-TCFAs were larger compared to non-VH-TCFAs (p = 0.002), while fibrofatty plaque areas were larger in non-VH-TCFAs (p < 0.0001). Ruptured plaque cavity size was correlated with distal reference lumen area (r = 0.521, p = 0.00002), minimum lumen area (r = 0.595, p < 0.0001), and plaque area (r = 0.267, p = 0.033). Sensitivity and specificity curve analysis showed that a minimum lumen area of 3.5 mm(2), a distal reference lumen area of 7.5 mm(2), and a maximum NC area of 35% best predicted plaque rupture. Although VH-TCFA (35 of 72) was the most frequent phenotype of plaque rupture in ST-segment elevation myocardial infarction, plaque rupture also occurred in non-VH-TCFA: pathologic intimal thickening (8 of 72), thick-capped fibroatheroma (1 of 72), and fibrotic (14 of 72) and fibrocalcified (14 of 72) plaque. In conclusion, not all culprit plaque ruptures in patients with ST-segment elevation myocardial infarction occur as a result of TCFA rupture; a prominent fibrofatty plaque, especially in a proximal vessel, may be another form of vulnerable plaque. Further study should identify additional factors causing plaque rupture. (C) 2012 Elsevier Inc. All rights reserved. (Am J Cardiol 2012;109: 794-799) | - |
dc.publisher | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | - |
dc.subject | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject | RADIOFREQUENCY | - |
dc.title | Relation of Ruptured Plaque Culprit Lesion Phenotype and Outcomes in Patients With ST Elevation Acute Myocardial Infarction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hahn, JY[Hahn, Joo Yong] | - |
dc.identifier.doi | 10.1016/j.amjcard.2011.10.042 | - |
dc.identifier.scopusid | 2-s2.0-84857781622 | - |
dc.identifier.wosid | 000301967500003 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF CARDIOLOGY, v.109, no.6, pp.794 - 799 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF CARDIOLOGY | - |
dc.citation.title | AMERICAN JOURNAL OF CARDIOLOGY | - |
dc.citation.volume | 109 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 794 | - |
dc.citation.endPage | 799 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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