4-O-methylascochlorin, methylated derivative of ascochlorin, stabilizes HIF-1 alpha via AMPK activation
DC Field | Value | Language |
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dc.contributor.author | Jeong, JH[Jeong, Ji-Hak] | - |
dc.contributor.author | Kang, JH[Kang, Jeong Han] | - |
dc.contributor.author | Hwang, SL[Hwang, Seung-Lark] | - |
dc.contributor.author | Cho, HJ[Cho, Hyun-Ji] | - |
dc.contributor.author | Park, KK[Park, Kwan-Kyu] | - |
dc.contributor.author | Park, YY[Park, Yoon-Yup] | - |
dc.contributor.author | Chung, IK[Chung, Il-Kyung] | - |
dc.contributor.author | Chang, HW[Chang, Hyeun-Wook] | - |
dc.contributor.author | Kim, CH[Kim, Cheorl-Ho] | - |
dc.contributor.author | Min, KS[Min, Kwan-Sik] | - |
dc.contributor.author | Kim, HD[Kim, Hong-Duck] | - |
dc.contributor.author | Magae, J[Magae, Junji] | - |
dc.contributor.author | Kang, SS[Kang, Shin-Sung] | - |
dc.contributor.author | Chang, YC[Chang, Young-Chae] | - |
dc.date.accessioned | 2021-08-06T01:59:41Z | - |
dc.date.available | 2021-08-06T01:59:41Z | - |
dc.date.created | 2016-08-06 | - |
dc.date.issued | 2011-03-18 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/70519 | - |
dc.description.abstract | Chemopreventive or anticancer agents induce cancer cells to apoptosis through the activation of adenosine AMP-activated protein kinase (AMPK), which plays a major role as energy sensors under ATP-deprived condition or ROS generation. In this study, we compared the effects of ascochlorin (ASC), from the fungus Ascochyta viciae, and its derivatives on AMPK activity. We also examined a regulatory mechanism for hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization in response to 4-O-methylascochlorin (MAC). We found that AMPK activation was mainly involved with MAC, but not ASC and 4-O-carboxymethylascochlorin (AS-6), indicating that the substitution of 4-O-methyl group from 4-O-hydroxyl group of ASC is important in the activation of AMPK and the expression of HIF-1 alpha. MAC-stabilized HIF-1 alpha via AMPK activation triggered by lowering the intracellular ATP level, not by ROS generation, increases glucose uptake and the expression of vascular endothelial growth factor (VEGF) and glucose transporter 1 (GLUT-1), major target genes of HIF-1 alpha. moreover, MAC-induced AMPK activity suppressed survival factors, including mTOR and ERK1/2 or translational regulators, including p70S6K and 4E-BP1. Our data suggest that AMPK is a key determinant of MAC-induced HIF-1 alpha expression in response to energy stress, further implying its involvement in MAC-induced apoptosis. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.title | 4-O-methylascochlorin, methylated derivative of ascochlorin, stabilizes HIF-1 alpha via AMPK activation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, CH[Kim, Cheorl-Ho] | - |
dc.identifier.doi | 10.1016/j.bbrc.2011.02.043 | - |
dc.identifier.scopusid | 2-s2.0-79952735476 | - |
dc.identifier.wosid | 000288973300009 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.406, no.3, pp.353 - 358 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 406 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 353 | - |
dc.citation.endPage | 358 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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