Saucerneol G, a New Lignan, from Saururus chinensis Inhibits Matrix Metalloproteinase-9 Induction via a Nuclear Factor kappa B and Mitogen Activated Protein Kinases in Lipopolysaccharide-Stimulated RAW264 7 Cells
DC Field | Value | Language |
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dc.contributor.author | Lu, Y[Lu, Yue] | - |
dc.contributor.author | Hong, TG[Hong, Tae Gyun] | - |
dc.contributor.author | Jin, MH[Jin, Meihua] | - |
dc.contributor.author | Yang, JH[Yang, Ju Hae] | - |
dc.contributor.author | Suh, SJ[Suh, Seok-Jong] | - |
dc.contributor.author | Piao, DG[Piao, Dong Gen] | - |
dc.contributor.author | Ko, HK[Ko, Hyun-Kwon] | - |
dc.contributor.author | Seo, CS[Seo, Chang-Seob] | - |
dc.contributor.author | Chang, YC[Chang, Young-Chae] | - |
dc.contributor.author | Kim, CH[Kim, Cheorl-Ho] | - |
dc.contributor.author | Son, JK[Son, Jong-Keun] | - |
dc.contributor.author | Chang, HW[Chang, Hyeun Wook] | - |
dc.date.accessioned | 2021-08-06T09:49:42Z | - |
dc.date.available | 2021-08-06T09:49:42Z | - |
dc.date.created | 2016-10-20 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/72781 | - |
dc.description.abstract | This study was conducted to demonstrate the inhibitory effect of saucerneol G (SG), a new lignan, Isolated from the aerial part of Saururus chinensis (Saururaceae) on lipopolysaccharide (LPS)-stimulated matrix metalloproteinase-9 (MMP)-9 inductions in RAW 264 7 cells Aimed at evaluating the mechanism of action by which SG inhibits the LPS-mediated induction of MMP-9, the effects of SG on nuclear factor-kappa B (NF-kappa B) DNA binding activity, NF-kappa B-dependent reporter gene activity, inhibitory factor-kappa B (I kappa B) phosphorylation, degradation and p65 nuclear translocation were assessed SG profoundly suppressed the DNA binding activity and the reporter gene activity as well as translocation of NF-kappa B p65 subunit Furthermore, SG also dose dependently inhibited LPS-stimulated activation of mitogen-activated protein kinases (MAPKs) These findings suggest that SG may inhibit LPS-stimulated MMP-9 induction by blocking NF-kappa B and MAPKs activation | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | TRANSACTIVATION ACTIVITY | - |
dc.subject | INOS EXPRESSION | - |
dc.subject | MANASSANTIN-A | - |
dc.subject | MMP-9 | - |
dc.subject | EXTRACT | - |
dc.subject | CERNUUS | - |
dc.subject | ROOTS | - |
dc.subject | ACID | - |
dc.subject | P38 | - |
dc.title | Saucerneol G, a New Lignan, from Saururus chinensis Inhibits Matrix Metalloproteinase-9 Induction via a Nuclear Factor kappa B and Mitogen Activated Protein Kinases in Lipopolysaccharide-Stimulated RAW264 7 Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, HK[Ko, Hyun-Kwon] | - |
dc.contributor.affiliatedAuthor | Kim, CH[Kim, Cheorl-Ho] | - |
dc.identifier.doi | 10.1248/bpb.33.1944 | - |
dc.identifier.scopusid | 2-s2.0-78751519896 | - |
dc.identifier.wosid | 000284862200004 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.33, no.12, pp.1944 - 1948 | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 33 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1944 | - |
dc.citation.endPage | 1948 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | TRANSACTIVATION ACTIVITY | - |
dc.subject.keywordPlus | INOS EXPRESSION | - |
dc.subject.keywordPlus | MANASSANTIN-A | - |
dc.subject.keywordPlus | MMP-9 | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | CERNUUS | - |
dc.subject.keywordPlus | ROOTS | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | P38 | - |
dc.subject.keywordAuthor | saucerneol G | - |
dc.subject.keywordAuthor | Saururus chinensis | - |
dc.subject.keywordAuthor | matrix metalloproteinase 9 | - |
dc.subject.keywordAuthor | nuclear factor kappa B | - |
dc.subject.keywordAuthor | mitogen activated protein kinase | - |
dc.subject.keywordAuthor | lipopolysaccharide | - |
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