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Butler enables rapid cloud-based analysis of thousands of human genomes

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dc.contributor.authorYakneen, S[Yakneen, Sergei]-
dc.contributor.authorWaszak, SM[Waszak, Sebastian M.]-
dc.contributor.authorGertz, M[Gertz, Michael]-
dc.contributor.authorKorbel, JO[Korbel, Jan O.]-
dc.contributor.authorAminou, B[Aminou, Brice]-
dc.contributor.authorBartolome, J[Bartolome, Javier]-
dc.contributor.authorBoroevich, KA[Boroevich, Keith A.]-
dc.contributor.authorBoyce, R[Boyce, Rich]-
dc.contributor.authorBrooks, AN[Brooks, Angela N.]-
dc.contributor.authorBuchanan, A[Buchanan, Alex]-
dc.contributor.authorBuchhalter, I[Buchhalter, Ivo]-
dc.contributor.authorButler, AP[Butler, Adam P.]-
dc.contributor.authorByrne, NJ[Byrne, Niall J.]-
dc.contributor.authorCafferkey, A[Cafferkey, Andy]-
dc.contributor.authorCampbell, PJ[Campbell, Peter J.]-
dc.contributor.authorChen, ZH[Chen, Zhaohong]-
dc.contributor.authorCho, S[Cho, Sunghoon]-
dc.contributor.authorChoi, W[Choi, Wan]-
dc.contributor.authorClapham, P[Clapham, Peter]-
dc.contributor.authorDavis-Dusenbery, BN[Davis-Dusenbery, Brandi N.]-
dc.contributor.authorDe La Vega, FM[De La Vega, Francisco M.]-
dc.contributor.authorDemeulemeester, J[Demeulemeester, Jonas]-
dc.contributor.authorDow, MT[Dow, Michelle T.]-
dc.contributor.authorDursi, LJ[Dursi, Lewis Jonathan]-
dc.contributor.authorEils, J[Eils, Juergen]-
dc.contributor.authorEils, R[Eils, Roland]-
dc.contributor.authorEllrott, K[Ellrott, Kyle]-
dc.contributor.authorFarcas, C[Farcas, Claudiu]-
dc.contributor.authorFavero, F[Favero, Francesco]-
dc.contributor.authorFayzullaev, N[Fayzullaev, Nodirjon]-
dc.contributor.authorFerretti, V[Ferretti, Vincent]-
dc.contributor.authorFlicek, P[Flicek, Paul]-
dc.contributor.authorFonseca, NA[Fonseca, Nuno A.]-
dc.contributor.authorGelpi, JL[Gelpi, Josep Ll]-
dc.contributor.authorGetz, G[Getz, Gad]-
dc.contributor.authorGibson, B[Gibson, Bob]-
dc.contributor.authorGrossman, RL[Grossman, Robert L.]-
dc.contributor.authorHarismendy, O[Harismendy, Olivier]-
dc.contributor.authorHeath, AP[Heath, Allison P.]-
dc.contributor.authorHeinold, MC[Heinold, Michael C.]-
dc.contributor.authorHess, JM[Hess, Julian M.]-
dc.contributor.authorHofmann, O[Hofmann, Oliver]-
dc.contributor.authorHong, JH[Hong, Jongwhi H.]-
dc.contributor.authorHudson, TJ[Hudson, Thomas J.]-
dc.contributor.authorHutter, B[Hutter, Barbara]-
dc.contributor.authorHutter, CM[Hutter, Carolyn M.]-
dc.contributor.authorHubschmann, D[Huebschmann, Daniel]-
dc.contributor.authorImoto, S[Imoto, Seiya]-
dc.contributor.authorIvkovic, S[Ivkovic, Sinisa]-
dc.contributor.authorJeon, SH[Jeon, Seung-Hyup]-
dc.contributor.authorJiao, W[Jiao, Wei]-
dc.contributor.authorJung, J[Jung, Jongsun]-
dc.contributor.authorKabbe, R[Kabbe, Rolf]-
dc.contributor.authorKahles, A[Kahles, Andre]-
dc.contributor.authorKerssemakers, JNA[Kerssemakers, Jules N. A.]-
dc.contributor.authorKim, HL[Kim, Hyung-Lae]-
dc.contributor.authorKim, H[Kim, Hyunghwan]-
dc.contributor.authorKim, J[Kim, Jihoon]-
dc.contributor.authorKim, Y[Kim, Youngwook]-
dc.contributor.authorKleinheinz, K[Kleinheinz, Kortine]-
dc.contributor.authorKoscher, M[Koscher, Michael]-
dc.contributor.authorKoures, A[Koures, Antonios]-
dc.contributor.authorKovacevic, M[Kovacevic, Milena]-
dc.contributor.authorLawerenz, C[Lawerenz, Chris]-
dc.contributor.authorLeshchiner, I[Leshchiner, Ignaty]-
dc.contributor.authorLiu, J[Liu, Jia]-
dc.contributor.authorLivitz, D[Livitz, Dimitri]-
dc.contributor.authorMihaiescu, GL[Mihaiescu, George L.]-
dc.contributor.authorMijalkovic, S[Mijalkovic, Sanja]-
dc.contributor.authorLazic, AM[Lazic, Ana Mijalkovic]-
dc.contributor.authorMiyano, S[Miyano, Satoru]-
dc.contributor.authorMiyoshi, N[Miyoshi, Naoki]-
dc.contributor.authorNahal-Bose, HK[Nahal-Bose, Hardeep K.]-
dc.contributor.authorNakagawa, H[Nakagawa, Hidewaki]-
dc.contributor.authorNastic, M[Nastic, Mia]-
dc.contributor.authorNewhouse, SJ[Newhouse, Steven J.]-
dc.contributor.authorNicholson, J[Nicholson, Jonathan]-
dc.contributor.authorO'Connor, BD[O'Connor, Brian D.]-
dc.contributor.authorOcana, D[Ocana, David]-
dc.contributor.authorOhi, K[Ohi, Kazuhiro]-
dc.contributor.authorOhno-Machado, L[Ohno-Machado, Lucila]-
dc.contributor.authorOmberg, L[Omberg, Larsson]-
dc.contributor.authorOuellette, BFF[Ouellette, B. F. Francis]-
dc.contributor.authorParamasivam, N[Paramasivam, Nagarajan]-
dc.contributor.authorPerry, MD[Perry, Marc D.]-
dc.contributor.authorPihl, TD[Pihl, Todd D.]-
dc.contributor.authorPrinz, M[Prinz, Manuel]-
dc.contributor.authorPuiggros, M[Puiggros, Montserrat]-
dc.contributor.authorRadovic, P[Radovic, Petar]-
dc.contributor.authorRaine, KM[Raine, Keiran M.]-
dc.contributor.authorRheinbay, E[Rheinbay, Esther]-
dc.contributor.authorRosenberg, M[Rosenberg, Mara]-
dc.contributor.authorRoyo, R[Royo, Romina]-
dc.contributor.authorRatsch, G[Raetsch, Gunnar]-
dc.contributor.authorSaksena, G[Saksena, Gordon]-
dc.contributor.authorSchlesner, M[Schlesner, Matthias]-
dc.contributor.authorShorser, SI[Shorser, Solomon, I]-
dc.contributor.authorShort, C[Short, Charles]-
dc.contributor.authorSofia, HJ[Sofia, Heidi J.]-
dc.contributor.authorSpring, J[Spring, Jonathan]-
dc.contributor.authorStein, LD[Stein, Lincoln D.]-
dc.contributor.authorStruck, AJ[Struck, Adam J.]-
dc.contributor.authorTiao, G[Tiao, Grace]-
dc.contributor.authorTijanic, N[Tijanic, Nebojsa]-
dc.contributor.authorTorrents, D[Torrents, David]-
dc.contributor.authorVan Loo, P[Van Loo, Peter]-
dc.contributor.authorVazquez, M[Vazquez, Miguel]-
dc.contributor.authorVicente, D[Vicente, David]-
dc.contributor.authorWala, JA[Wala, Jeremiah A.]-
dc.contributor.authorWang, ZN[Wang, Zhining]-
dc.contributor.authorWeischenfeldt, J[Weischenfeldt, Joachim]-
dc.contributor.authorWerner, J[Werner, Johannes]-
dc.contributor.authorWilliams, A[Williams, Ashley]-
dc.contributor.authorWoo, Y[Woo, Youngchoon]-
dc.contributor.authorWright, AJ[Wright, Adam J.]-
dc.contributor.authorXiang, Q[Xiang, Qian]-
dc.contributor.authorYang, LM[Yang, Liming]-
dc.contributor.authorYuen, D[Yuen, Denis]-
dc.contributor.authorYung, CK[Yung, Christina K.]-
dc.contributor.authorZhang, JJ[Zhang, Junjun]-
dc.date.accessioned2021-07-28T14:53:07Z-
dc.date.available2021-07-28T14:53:07Z-
dc.date.created2020-08-10-
dc.date.issued2020-03-
dc.identifier.issn1087-0156-
dc.identifier.urihttps://scholarworks.bwise.kr/skku/handle/2021.sw.skku/7636-
dc.description.abstractEfficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities. We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.-
dc.language영어-
dc.language.isoen-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectVARIANT DISCOVERY-
dc.titleButler enables rapid cloud-based analysis of thousands of human genomes-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Y[Kim, Youngwook]-
dc.identifier.doi10.1038/s41587-019-0360-3-
dc.identifier.scopusid2-s2.0-85079041410-
dc.identifier.wosid000511288100001-
dc.identifier.bibliographicCitationNATURE BIOTECHNOLOGY, v.38, no.3, pp.288 - 292-
dc.relation.isPartOfNATURE BIOTECHNOLOGY-
dc.citation.titleNATURE BIOTECHNOLOGY-
dc.citation.volume38-
dc.citation.number3-
dc.citation.startPage288-
dc.citation.endPage292-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiotechnology & Applied Microbiology-
dc.relation.journalWebOfScienceCategoryBiotechnology & Applied Microbiology-
dc.subject.keywordPlusVARIANT DISCOVERY-
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