1,5-Anhydroglucitol reflects postprandial hyperglycemia and a decreased insulinogenic index, even in subjects with prediabetes and well-controlled type 2 diabetes
DC Field | Value | Language |
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dc.contributor.author | Won, JC[Won, Jong Chul] | - |
dc.contributor.author | Park, CY[Park, Cheol-Young] | - |
dc.contributor.author | Park, HS[Park, Hyo-Soon] | - |
dc.contributor.author | Kim, JH[Kim, Ji Hoom] | - |
dc.contributor.author | Choi, ES[Choi, Eun Sook] | - |
dc.contributor.author | Rhee, EJ[Rhee, Eun Jung] | - |
dc.contributor.author | Lee, WY[Lee, Won Young] | - |
dc.contributor.author | Oh, KW[Oh, Ki Won] | - |
dc.contributor.author | Kim, SW[Kim, Sun Woo] | - |
dc.contributor.author | Park, SW[Park, Sung Woo] | - |
dc.date.accessioned | 2021-08-07T03:57:57Z | - |
dc.date.available | 2021-08-07T03:57:57Z | - |
dc.date.created | 2016-10-20 | - |
dc.date.issued | 2009-04 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/78193 | - |
dc.description.abstract | To examine the serum 1,5-anhydroglucitol (AG) levels as a surrogate measure of postprandial hyperglycemia (PPH) and insulin secretion in a wide range of hyperglycemia, we compared the relationship between the glycemic index during a 75 g oral glucose tolerance test (OGTT) and the insulinogenic index and 1,5-AG according the overall glycemic state. Fasting serum 1,5-AG levels were lower in the type 2 diabetic group (18.0 +/- 7.0 mu g/mL) than in the normal glucose tolerance (NGT, 25.4 +/- 4.0 mu g/mL), impaired fasting glucose (IFG, 24.6 +/- 6.2 mu g/mL), and impaired glucose tolerance (IGT, 22.1 +/- 6.2 mu g/mL) groups and were clearly correlated with glycemic values from the OGTT. 120-min post-challenge plasma glucose (PPG(120)) emerged as an independent predictor for 1,5-AG levels after multiple linear regression analysis (beta = -0.554, P < 0.001). Additionally, 1,5-AG levels were significantly correlated with PPG120 in each quartile of A1C, and the coefficients increased with higher A1C quartiles. Subjects with low 1,5-AG levels had both increased insulin resistance and decreased insulin secretion. Decreased 1,5-AG levels are closely correlated with PPH and decreased insulin secretion capacity across a wide range of glycemia, even in relatively well-controlled diabetes. (C) 2009 Elsevier Ireland Ltd. All rights reserved. | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | HOMEOSTASIS MODEL ASSESSMENT | - |
dc.subject | FASTING PLASMA-GLUCOSE | - |
dc.subject | SERUM 1,5-ANHYDROGLUCITOL | - |
dc.subject | GLYCEMIC CONTROL | - |
dc.subject | BLOOD-GLUCOSE | - |
dc.subject | CLINICAL MARKER | - |
dc.subject | RISK-FACTOR | - |
dc.subject | COMPLICATIONS | - |
dc.subject | MELLITUS | - |
dc.subject | 1,5-ANHYDRO-D-GLUCITOL | - |
dc.title | 1,5-Anhydroglucitol reflects postprandial hyperglycemia and a decreased insulinogenic index, even in subjects with prediabetes and well-controlled type 2 diabetes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Won, JC[Won, Jong Chul] | - |
dc.contributor.affiliatedAuthor | Park, CY[Park, Cheol-Young] | - |
dc.contributor.affiliatedAuthor | Park, HS[Park, Hyo-Soon] | - |
dc.contributor.affiliatedAuthor | Rhee, EJ[Rhee, Eun Jung] | - |
dc.contributor.affiliatedAuthor | Lee, WY[Lee, Won Young] | - |
dc.contributor.affiliatedAuthor | Oh, KW[Oh, Ki Won] | - |
dc.contributor.affiliatedAuthor | Park, SW[Park, Sung Woo] | - |
dc.identifier.doi | 10.1016/j.diabres.2009.01.002 | - |
dc.identifier.scopusid | 2-s2.0-62049085193 | - |
dc.identifier.wosid | 000265329300008 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, v.84, no.1, pp.51 - 57 | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.citation.title | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.citation.volume | 84 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 51 | - |
dc.citation.endPage | 57 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | HOMEOSTASIS MODEL ASSESSMENT | - |
dc.subject.keywordPlus | FASTING PLASMA-GLUCOSE | - |
dc.subject.keywordPlus | SERUM 1,5-ANHYDROGLUCITOL | - |
dc.subject.keywordPlus | GLYCEMIC CONTROL | - |
dc.subject.keywordPlus | BLOOD-GLUCOSE | - |
dc.subject.keywordPlus | CLINICAL MARKER | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | COMPLICATIONS | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | 1,5-ANHYDRO-D-GLUCITOL | - |
dc.subject.keywordAuthor | 1,5-Anhydroglucitol (1,5-AG) | - |
dc.subject.keywordAuthor | Postprandial hyperglycemia | - |
dc.subject.keywordAuthor | Insulinogenic index | - |
dc.subject.keywordAuthor | Prediabetes | - |
dc.subject.keywordAuthor | Diabetes | - |
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