Topical application of galgeunhwanggeumhwangryeon-tang recovers skin-lipid barrier and ameliorates inflammation via filaggrin-thymic stromal lymphopoietin-interleukin 4 pathway
DC Field | Value | Language |
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dc.contributor.author | Ahn, S.-H.[Ahn, S.-H.] | - |
dc.contributor.author | Shin, S.[Shin, S.] | - |
dc.contributor.author | Do, Y.[Do, Y.] | - |
dc.contributor.author | Jo, Y.[Jo, Y.] | - |
dc.contributor.author | Ryu, D.[Ryu, D.] | - |
dc.contributor.author | Ha, K.-T.[Ha, K.-T.] | - |
dc.contributor.author | Kim, K.[Kim, K.] | - |
dc.date.accessioned | 2022-01-13T01:50:18Z | - |
dc.date.available | 2022-01-13T01:50:18Z | - |
dc.date.created | 2022-01-13 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/94611 | - |
dc.description.abstract | Background and objectives: The purpose of this study was to confirm the effect of Galgeunhwanggeumhwangryeon-tang (GGRT) on the skin barrier integrity and inflammation in an atopic dermatitis-like animal model. Materials and Methods: The model was established using lipid barrier elimination (LBE) in BALB/c mice. Ceramide 3B, a control drug, and GGRT were applied to the skin of LBE mice. Gross observation and histological examination were combined with measurement of skin score, trans-epidermal water loss, and pH. The expression of filaggrin, kallikrein-related peptidase 7 (KLK7), protease-activated receptor-2 (PAR-2), thymic stromal lymphopoietin (TSLP), and interleukin 4 (IL-4) was examined. Results: The effect of GGRT on atopic dermatitis was estimated in silico using two individual gene sets of human atopic dermatitis. In animal experiments, GGRT treatment reduced atopic dermatitis-like symptoms, as confirmed via gross and histological observations, skin score, pH change, and trans-epidermal water loss. The expression level of filaggrin increased in the skin of GGRT-treated mice compared to that in the LBE group. The expression levels of KLK7, PAR2, TSLP, and IL-4 were decreased in GGRT-treated mice skin compared to those in LBE mice. Conclusions: We demonstrated that GGRT restored the skin barrier and reduced inflammatory reactions in a murine model of atopic dermatitis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Topical application of galgeunhwanggeumhwangryeon-tang recovers skin-lipid barrier and ameliorates inflammation via filaggrin-thymic stromal lymphopoietin-interleukin 4 pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, D.[Ryu, D.] | - |
dc.identifier.doi | 10.3390/medicina57121387 | - |
dc.identifier.scopusid | 2-s2.0-85121579611 | - |
dc.identifier.wosid | 000735850900001 | - |
dc.identifier.bibliographicCitation | Medicina (Lithuania), v.57, no.12 | - |
dc.relation.isPartOf | Medicina (Lithuania) | - |
dc.citation.title | Medicina (Lithuania) | - |
dc.citation.volume | 57 | - |
dc.citation.number | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | EPIDERMAL BARRIER | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TSLP | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | COMPONENTS | - |
dc.subject.keywordPlus | DECOCTION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.subject.keywordAuthor | Ceramide | - |
dc.subject.keywordAuthor | Filaggrin | - |
dc.subject.keywordAuthor | Galgeunhwanggeumhwangryeon-tang | - |
dc.subject.keywordAuthor | IL-4 | - |
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