Association Between the Persistence of Obesity and the Risk of Gastric Cancer: A Nationwide Population-Based Studyopen accessAssociation Between the Persistence of Obesity and the Risk of Gastric Cancer: A Nationwide Population-Based Study
- Other Titles
- Association Between the Persistence of Obesity and the Risk of Gastric Cancer: A Nationwide Population-Based Study
- Authors
- 임주현; 신철민; 한경도; 이승우; 진은효; 최윤진; 윤혁; 박영수; 김나영; 이동호
- Issue Date
- Jan-2022
- Publisher
- 대한암학회
- Keywords
- Obesity; Stomach neoplasms; Dose-response relationship
- Citation
- Cancer Research and Treatment, v.54, no.1, pp.199 - 207
- Journal Title
- Cancer Research and Treatment
- Volume
- 54
- Number
- 1
- Start Page
- 199
- End Page
- 207
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/41683
- DOI
- 10.4143/crt.2021.130
- ISSN
- 1598-2998
- Abstract
- Purpose There remains controversy about relationship between obesity and gastric cancer. We aimed to examine the association using obesity-persistence.
Materials and Methods We analyzed a nationwide population-based cohort which underwent health check-up between 2009 and 2012. Among them, those who had annual examinations during the last 5 years were selected. Gastric cancer risk was compared between those without obesity during the 5 years (never-obesity group) and those with obesity diagnosis during the 5 years (non-persistent obesity group; persistent obesity group).
Results Among 2,757,017 individuals, 13,441 developed gastric cancer after median 6.78 years of follow-up. Gastric cancer risk was the highest in persistent obesity group (incidence rate [IR], 0.89/1,000 person-years; hazard ratio [HR], 1.197; 95% confidence interval [CI], 1.117 to 1.284), followed by non-persistent obesity group (IR, 0.83/1,000 person-years; HR, 1.113; 95% CI, 1.056 to 1.172) compared with never-obesity group. In subgroup analysis, this positive relationship was true among those < 65 years old and male. Among heavy-drinkers, the impact of obesity-persistence on the gastric cancer risk far increased (non-persistent obesity: HR, 1.297; 95% CI, 1.094 to 1.538; persistent obesity: HR, 1.351; 95% CI, 1.076 to 1.698).
Conclusion Obesity-persistence is associated with increased risk of gastric cancer in a dose-response manner, especially among male < 65 years old. The risk raising effect was much stronger among heavy-drinkers.
- Files in This Item
-
Go to Link
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.