Evaluation of the Paradoxical Association Between Lipid Levels and Incident Atrial Fibrillation According to Statin Usage: A Nationwide Cohort Study
DC Field | Value | Language |
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dc.contributor.author | 안효정 | - |
dc.contributor.author | Lee So-Ryoung | - |
dc.contributor.author | 최의근 | - |
dc.contributor.author | 이승우 | - |
dc.contributor.author | 한경도 | - |
dc.contributor.author | 권순 | - |
dc.contributor.author | 오세일 | - |
dc.contributor.author | Gregory Y. H. Lip | - |
dc.date.accessioned | 2023-02-16T06:40:03Z | - |
dc.date.available | 2023-02-16T06:40:03Z | - |
dc.date.created | 2023-02-15 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2287-2892 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43241 | - |
dc.description.abstract | Objective Higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are associated with a lower risk of atrial fibrillation (AF). Statin use might exert confounding effects on the paradoxical associations; however, the relationships that distinguish statin users from non-users have not been thoroughly evaluated. Methods From the Korean National Health Insurance Database, we included 9,778,014 adults who underwent a health examination in 2009. The levels of TC and LDL-C at the health examination were categorized into quartile values of the total study population. We grouped the study population into statin users and non-users and investigated the associations between TC, LDL-C, and the risk of incident AF. Results Of the total population, 867,336 (8.9%) were taking statins. During a mean follow-up of 8.2 years, inverse associations of TC – AF and LDL-C – AF were observed; higher levels of TC and LDL-C were associated with the lower risk of AF in the total population. Overall, statin users showed higher AF incidence rate than non-users, but the inverse associations of TC – AF and LDL-C – AF were consistently observed irrespective of statin usage; adjusted hazard ratio with 95% confidence interval was 0.81 (0.79–0.84) for statin users and 0.81 (0.80–0.83) for non-users in the highest TC quartile, and 0.84 (0.82–0.87) for statin users and 0.85 (0.84–0.86) for non-users in the highest LDL-C quartile (all p<0.001). Conclusion The paradoxical relationship between lipid levels (TC and LDL-C) and the risk of AF remains consistent in both statin users and non-users. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국지질동맥경화학회 | - |
dc.relation.isPartOf | 지질·동맥경화학회지 | - |
dc.title | Evaluation of the Paradoxical Association Between Lipid Levels and Incident Atrial Fibrillation According to Statin Usage: A Nationwide Cohort Study | - |
dc.title.alternative | Evaluation of the Paradoxical Association Between Lipid Levels and Incident Atrial Fibrillation According to Statin Usage: A Nationwide Cohort Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.12997/jla.2023.12.1.73 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | 지질·동맥경화학회지, v.12, no.1, pp.73 - 86 | - |
dc.identifier.kciid | ART002926260 | - |
dc.description.journalClass | 1 | - |
dc.identifier.scopusid | 2-s2.0-85147157114 | - |
dc.citation.endPage | 86 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 73 | - |
dc.citation.title | 지질·동맥경화학회지 | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | 한경도 | - |
dc.identifier.url | https://e-jla.org/DOIx.php?id=10.12997/jla.2023.12.1.73 | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Atrial fibrillation | - |
dc.subject.keywordAuthor | Cholesterol | - |
dc.subject.keywordAuthor | Association | - |
dc.subject.keywordAuthor | Lipid | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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