Changes in Alcohol Consumption and Risk of Dementia in a Nationwide Cohort in South Korea
DC Field | Value | Language |
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dc.contributor.author | Jeon, K.H. | - |
dc.contributor.author | Han, K. | - |
dc.contributor.author | Jeong, S.-M. | - |
dc.contributor.author | Park, J. | - |
dc.contributor.author | Yoo, J.E. | - |
dc.contributor.author | Yoo, J. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Shin, D.W. | - |
dc.date.accessioned | 2023-09-25T08:40:12Z | - |
dc.date.available | 2023-09-25T08:40:12Z | - |
dc.date.created | 2023-07-07 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 2574-3805 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/44295 | - |
dc.description.abstract | Importance: The impact of serial changes in alcohol consumption on dementia risk has rarely been investigated to date. Objective: To investigate the association of comprehensive patterns of changes in alcohol consumption with the incidence of all-cause dementia, Alzheimer disease (AD), and vascular dementia (VaD). Design, Setting, and Participants: This is a retrospective cohort study. Data were obtained from the Korean National Health Insurance Service database. Adults aged 40 years and older underwent 2 health examinations in 2009 and 2011. The cohort was assessed until December 31, 2018, and statistical analysis was performed in December 2021. Exposures: Alcohol consumption level was categorized into none (0 g per day), mild (<15 g per day), moderate (15-29.9 g per day), and heavy (≥30 g per day) drinking. On the basis of changes in alcohol consumption level from 2009 to 2011, participants were categorized into the following groups: nondrinker, quitter, reducer, sustainer, and increaser. Main Outcomes and Measures: The primary outcome was newly diagnosed AD, VaD, or other dementia. Results: Among 3 933 382 participants (mean [SD] age, 55.0 [9.6] years; 2 037 948 men [51.8%]), during a mean (SD) follow-up of 6.3 (0.7) years, there were 100 282 cases of all-cause dementia, 79 982 cases of AD, and 11 085 cases of VaD. Compared with sustained nondrinking, sustained mild (adjusted hazard ratio [aHR], 0.79; 95% CI, 0.77-0.81) and moderate (aHR, 0.83; 95% CI, 0.79-0.88) drinking were associated with a decreased risk of all-cause dementia, whereas sustained heavy drinking was associated with an increased risk of all-cause dementia (aHR, 1.08; 95% CI, 1.03-1.12). Compared with sustained levels of drinking, reducing alcohol consumption from a heavy to a moderate level (aHR, 0.92; 95% CI, 0.86-0.99) and the initiation of mild alcohol consumption (aHR, 0.93; 95% CI, 0.90-0.96) were associated with a decreased risk of all-cause dementia. Increasers and quitters exhibited an increased risk of all-cause dementia compared with sustainers. The trends in AD and VaD remained consistent. Conclusions and Relevance: In this cohort study of a Korean population, decreased risk of dementia was associated with maintaining mild to moderate alcohol consumption, reducing alcohol consumption from a heavy to a moderate level, and the initiation of mild alcohol consumption, suggesting that the threshold of alcohol consumption for dementia risk reduction is low. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NLM (Medline) | - |
dc.relation.isPartOf | JAMA network open | - |
dc.title | Changes in Alcohol Consumption and Risk of Dementia in a Nationwide Cohort in South Korea | - |
dc.type | Article | - |
dc.identifier.doi | 10.1001/jamanetworkopen.2022.54771 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JAMA network open, v.6, no.2, pp.e2254771 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001059434300006 | - |
dc.identifier.scopusid | 2-s2.0-85147536358 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e2254771 | - |
dc.citation.title | JAMA network open | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Han, K. | - |
dc.identifier.url | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800994 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | DOSE-RESPONSE METAANALYSIS | - |
dc.subject.keywordPlus | VARIABILITY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | DRINKING | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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