Type 2 diabetes and its genetic susceptibility are associated with increased severity and mortality of COVID-19 in UK Biobank
DC Field | Value | Language |
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dc.contributor.author | Lee, Aeyeon | - |
dc.contributor.author | Seo, Jieun | - |
dc.contributor.author | Park, Seunghwan | - |
dc.contributor.author | Cho, Youngkwang | - |
dc.contributor.author | Kim, Gaeun | - |
dc.contributor.author | Li, Jun | - |
dc.contributor.author | Liang, Liming | - |
dc.contributor.author | Park, Taesung | - |
dc.contributor.author | Chung, Wonil | - |
dc.date.accessioned | 2024-02-16T01:30:19Z | - |
dc.date.available | 2024-02-16T01:30:19Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 2399-3642 | - |
dc.identifier.issn | 2399-3642 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/49171 | - |
dc.description.abstract | Type 2 diabetes (T2D) is known as one of the important risk factors for the severity and mortality of COVID-19. Here, we evaluate the impact of T2D and its genetic susceptibility on the severity and mortality of COVID-19, using 459,119 individuals in UK Biobank. Utilizing the polygenic risk scores (PRS) for T2D, we identified a significant association between T2D or T2D PRS, and COVID-19 severity. We further discovered the efficacy of vaccination and the pivotal role of T2D-related genetics in the pathogenesis of severe COVID-19. Moreover, we found that individuals with T2D or those in the high T2D PRS group had a significantly increased mortality rate. We also observed that the mortality rate for SARS-CoV-2-infected patients was approximately 2 to 7 times higher than for those not infected, depending on the time of infection. These findings emphasize the potential of T2D PRS in estimating the severity and mortality of COVID-19. Study of 459,119 UK Biobank participants reveals that type 2 diabetes (T2D) and a high genetic susceptibility to T2D significantly increase the severity and mortality rate in COVID-19 cases. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Type 2 diabetes and its genetic susceptibility are associated with increased severity and mortality of COVID-19 in UK Biobank | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s42003-024-05799-1 | - |
dc.identifier.bibliographicCitation | COMMUNICATIONS BIOLOGY, v.7, no.1 | - |
dc.identifier.wosid | 001150568100006 | - |
dc.identifier.scopusid | 2-s2.0-85183017996 | - |
dc.citation.number | 1 | - |
dc.citation.title | COMMUNICATIONS BIOLOGY | - |
dc.citation.volume | 7 | - |
dc.identifier.url | https://www.nature.com/articles/s42003-024-05799-1 | - |
dc.publisher.location | 독일 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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