Sustained-Release Drug Delivery Potential of Antibiotic-Montmorillonite Composites Prepared Using Montmorillonite Mined in Gampo, Republic of Korea
- Authors
- Kim, Myungjae; Roh, Ki-Min; Kim, Jiwoo; Seo, Minkyeong; Kang, Il-Mo; Kim, Jiwoong
- Issue Date
- Feb-2022
- Publisher
- SPRINGER
- Keywords
- Acid treatment; Vibratory ball mill; Ciprofloxacin; Drug delivery; Montmorillonite; Sustained release
- Citation
- CLAYS AND CLAY MINERALS, v.70, no.1, pp.62 - 71
- Journal Title
- CLAYS AND CLAY MINERALS
- Volume
- 70
- Number
- 1
- Start Page
- 62
- End Page
- 71
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/42350
- DOI
- 10.1007/s42860-022-00172-x
- ISSN
- 0009-8604
- Abstract
- Biocompatible drug-delivery materials are important because they provide controlled release of biologically active agents to enhance the effectiveness of medical treatments. Montmorillonite (Mnt) has been utilized in drug-delivery systems for delayed-release application because it can safely encapsulate drug molecules via intercalation reactions. The objective of the present study was to evaluate the delivery characteristics of the drug ciprofloxacin (CIP) from a composite with Mnt (Mnt-CIP) in which the Mnt was first prepared by acid treatment and vibration ball milling. The surfaces of Mnt were modified by reacting the Mnt suspension in 1.0 M HCl acid and by dispersing the powder with a vibration ball mill, then the CIP drug was added at pH 4 and stirred. The goal was to improve the sustained-release performance of the CIP. This Mnt-CIP drug-release system was characterized by X-ray diffraction, X-ray fluorescence analysis, Fourier-transform infrared spectroscopy, surface area measurement using the Brunauer-Emmett-Teller (BET) method, and ultraviolet spectroscopy. The X-ray diffraction results confirmed the intercalation of CIP into the interlayer space of Mnt. The in vitro release properties of the intercalated CIP were investigated using a simulated phosphate-buffered saline solution (pH 7.4) at 36 +/- 0.5 degrees C. The CIP drug exhibited a continued release for 3 h. Moreover, Mnt prepared by HCl acid treatment and dispersion in the vibration ball mill delayed the drug dissolution rate. In summary, the Mnt-CIP composite prepared in this study exhibited slow and sustained release characteristics, indicating that Mnt mined from the Gampo-40 mining area in Gyeongju can be used in various drug-delivery applications.
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