Anti-inflammatory Effects of Flavonoids on TNBS-induced Colitis of Rats
DC Field | Value | Language |
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dc.contributor.author | Joo, Minjae | - |
dc.contributor.author | Kim, Han Sang | - |
dc.contributor.author | Kwon, Tae Loon | - |
dc.contributor.author | Palikhe, Alisha | - |
dc.contributor.author | Zaw, Tin Sandar | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Sohn, Uy Dong | - |
dc.date.available | 2019-03-08T18:01:19Z | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/10023 | - |
dc.description.abstract | It has been shown that the extracts including eupatilin and quercetin-3- beta -D-glucuronopyranoside had mucoprotective effects on the esophagus and stomach through their antioxidant activities. This study was designed to investigate the anti-inflammatory effect of these flavonoid compounds in an animal model of inflammatory bowel disease induced by 2,4,6-trinitrobenzene sulfonic acid. Experimental colitis was induced by intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid. Extracts including eupatilin or quercetin-3- beta -D-glucuronopyranoside were orally administered to animals 48, 24, and 1 h prior to the induction of colitis and then again 24 h later. The animals were sacrificed 48 h after by 2,4,6-trinitrobenzene sulfonic acid treatment and the macroscopic appearance of the colonic lesions was scored in a blinded manner on a scale of 1 to 10. The inflammatory response to colitis induction was assessed by measuring myeloperoxidase activity, nitric oxide production, tumor necrosis factor- alpha expression, total glutathione levels, and malondialdehyde concentrations in the colon. The results indicated that extracts including eupatilin and extracts including quercetin-3- beta -D-glucuronopyranoside dose-dependently improved the morphology of the lesions induced by 2,4,6-trinitrobenzene sulfonic acid and reduced the ulcer index accordingly. In addition, rats receiving extracts including eupatilin and extracts including quercetin-3-,beta -D-glucuronopyranoside showed significantly decreased levels of mucosal myeloperoxidase activity, nitric oxide production, tumor necrosis factor- alpha expression, and malondialdehyde levels, and increased total glutathione levels. Extracts including eupatilin and extracts including quercetin-3- beta -D-glucuronopyranoside ameliorated the inflammatory response and colonic injury in acute colitis by decreasing oxidative stress and neutrophil activation. Extracts including eupatilin and extracts including quercetin-3- beta -D-glucuronopyranoside may inhibit acute colitis. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | Anti-inflammatory Effects of Flavonoids on TNBS-induced Colitis of Rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2015.19.1.43 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.19, no.1, pp 43 - 50 | - |
dc.identifier.kciid | ART001945472 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000347747200007 | - |
dc.identifier.scopusid | 2-s2.0-84921489646 | - |
dc.citation.endPage | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 43 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 19 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Colitis | - |
dc.subject.keywordAuthor | Flavonoids | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Quercetin | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | ULCERATIVE-COLITIS | - |
dc.subject.keywordPlus | REFLUX ESOPHAGITIS | - |
dc.subject.keywordPlus | CROHNS-DISEASE | - |
dc.subject.keywordPlus | SULFONIC-ACID | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | SYNTHASE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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