ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
DC Field | Value | Language |
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dc.contributor.author | Song, Yu Seok | - |
dc.contributor.author | Balcos, Marie Carmel | - |
dc.contributor.author | Yun, Hye-Young | - |
dc.contributor.author | Baek, Kwang Jin | - |
dc.contributor.author | Kwon, Nyoun Soo | - |
dc.contributor.author | Kim, Myo-Kyoung | - |
dc.contributor.author | Kim, Dong-Seok | - |
dc.date.available | 2019-03-08T18:01:21Z | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/10024 | - |
dc.description.abstract | Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeophyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigrnentation is not fully understood. This study investigated the effects of fucoidan on melanogenesis and related signaling pathways using Mel-Ab cells. Fucoidan significantly decreased melanin content. While fucoidan treatment decreased tyrosinase activity, it did not do so directly. Western blot analysis indicated that fucoidan downregulated microphthalmia-associated transcription factor and reduced tyrosinase protein expression. Further investigation showed that fucoidan activated the extracellular signal-regulated kinase (ERK) pathway, suggesting a possible mechanism for the inhibition of melanin synthesis. Treatment with PD98059, a specific ERK inhibitor, resulted in the recovery of melanin production. Taken together, these findings suggest that fucoidan inhibits melanogenesis via ERK phosphorylation. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2015.19.1.29 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.19, no.1, pp 29 - 34 | - |
dc.identifier.kciid | ART001945438 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000347747200005 | - |
dc.identifier.scopusid | 2-s2.0-84921452831 | - |
dc.citation.endPage | 34 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 29 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 19 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | Fucoidan | - |
dc.subject.keywordAuthor | Melanogenesis | - |
dc.subject.keywordAuthor | MITF | - |
dc.subject.keywordAuthor | Tyrosinase | - |
dc.subject.keywordPlus | DECREASES MELANIN SYNTHESIS | - |
dc.subject.keywordPlus | SIGNAL-REGULATED KINASE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SARGASSUM-POLYCYSTUM | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PIGMENTATION | - |
dc.subject.keywordPlus | MELANOCYTES | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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