The association of 5-alpha reductase type 2 (SRD5A2) gene polymorphisms with prostate cancer in a Korean population
DC Field | Value | Language |
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dc.contributor.author | Choi, Se Young | - |
dc.contributor.author | Kim, Hae Jong | - |
dc.contributor.author | Cheong, Hyun Sub | - |
dc.contributor.author | Myung, Soon Chul | - |
dc.date.available | 2019-03-08T18:02:19Z | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 2005-6737 | - |
dc.identifier.issn | 2005-6745 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/10067 | - |
dc.description.abstract | Purpose: Steroid 5-alpha reductase type 2 (SRD5A2) modifies testosterone to dihydrotestosterone (DHT) in the prostate. Single-nucleotide polymorphisms (SNPs) of the SRD5A2 gene might affect DHT. We sought to understand the relationship of SRD5A2 SNPs to prostate cancer in the Korean population. Materials and Methods: Twenty-six common SNPs in the SRD5A2 gene were assessed in 272 prostate cancer cases and 173 controls. Single-locus analyses were conducted by using conditional logistic regression. Additionally, we performed a haplotype analysis for the SRD5A2 SNPs tested. Results: Among the 20 SNPs and 4 haplotypes, there were no statistically significant results in the prostate cancer patients and the controls. In the logistic analysis of SRD5A2 polymorphisms with prostate-specific antigen (PSA) criteria, two SNPs (rs508562, rs11675297) and haplotype 1 displayed significant results (odds ratio [OR], 1.76; p=0.05; OR, 1.88-2.02; p=0.01-0.04; OR, 0.59; p=0.02, respectively). rs508562, rs11675297, rs2208532, and haplotype 1 (OR, 1.49; p=0.05; OR, 2.02; p=0.05; OR, 2.01; p=0.04; OR, 0.56-0.64, p=0.03-0.04, respectively) had significant associations with Gleason score. rs508562, rs11675297, and haplotype 1 (OR, 1.41-2.34; p=0.004-0.05; OR, 1.74-1.82; p=0.03-0.05; OR, 0.42-0.67; p=0.0005-0.03, respectively) were significantly associated with clinical stage. Conclusions: We conclude that there was no significant association between SRD5A2 SNPs and the risk of prostate cancer in the Korean population. However, we found that some SNPs and 1 haplotype influenced PSA level, Gleason score, and clinical stage. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN UROLOGICAL ASSOC | - |
dc.title | The association of 5-alpha reductase type 2 (SRD5A2) gene polymorphisms with prostate cancer in a Korean population | - |
dc.type | Article | - |
dc.identifier.doi | 10.4111/kju.2015.56.1.19 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF UROLOGY, v.56, no.1, pp 19 - 29 | - |
dc.identifier.kciid | ART001956709 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000358438700004 | - |
dc.identifier.scopusid | 2-s2.0-84920947776 | - |
dc.citation.endPage | 29 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 19 | - |
dc.citation.title | KOREAN JOURNAL OF UROLOGY | - |
dc.citation.volume | 56 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Genetic polymorphism | - |
dc.subject.keywordAuthor | Human SRD5A2 protein | - |
dc.subject.keywordAuthor | Prostatic neoplasms | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | 5 ALPHA-REDUCTASE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | DIHYDROTESTOSTERONE | - |
dc.subject.keywordPlus | DISEQUILIBRIUM | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | SUBSTITUTION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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