Changes in blood and urinary cadmium levels and bone mineral density according to osteoporosis medication in individuals with an increased cadmium body burden
DC Field | Value | Language |
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dc.contributor.author | Eom, S-Y | - |
dc.contributor.author | Yim, D-H | - |
dc.contributor.author | Hong, S-M | - |
dc.contributor.author | Kim, Y-D | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Choi, Byung Sun | - |
dc.contributor.author | Park, Jung Duck | - |
dc.contributor.author | Park, C-H | - |
dc.contributor.author | Kim, G-B | - |
dc.contributor.author | Yu, S-D | - |
dc.date.available | 2019-01-22T13:30:00Z | - |
dc.date.issued | 2018-04-01 | - |
dc.identifier.issn | 0960-3271 | - |
dc.identifier.issn | 1477-0903 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1027 | - |
dc.description.abstract | The aim of this study was to assess changes in bone mineral density (BMD) and cadmium (Cd) levels in blood and urine in individuals living in a Cd-contaminated area according to the type of osteoporosis medication over a three-year period. This follow-up study included 204 residents living in the vicinity of a closed copper refinery, who had been found to have elevated urinary or blood Cd levels. Cd levels in the blood and urine, as well as BMD, were measured every 6 months. After the first BMD measurement, individuals were prescribed antiresorptives such as alendronate or vitamin D and calcium, according to their BMD. Subjects were classified according to the type of medicine provided over the previous 6 months. General linear models controlling for other factors were used to evaluate the effects of each type of medication on the participants' Cd levels and BMD. Spinal BMD showed a significant increase in the antiresorptive group compared to the nontreatment group. Significant decreases in blood Cd levels were found in the vitamin D and calcium group, in comparison to the nontreatment group, as well as a marginally significant decrease in the antiresorptive group. The vitamin D and calcium group showed a significantly greater decrease in urinary Cd levels than the nontreatment group. In contrast, antiresorptive medication was found to have a negative effect on urinary Cd excretion. These results suggest that vitamin D and calcium treatment for osteoporosis lowers blood Cd levels more effectively and improves urinary Cd excretion. | - |
dc.format.extent | 8 | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.title | Changes in blood and urinary cadmium levels and bone mineral density according to osteoporosis medication in individuals with an increased cadmium body burden | - |
dc.type | Article | - |
dc.identifier.doi | 10.1177/0960327117705425 | - |
dc.identifier.bibliographicCitation | HUMAN & EXPERIMENTAL TOXICOLOGY, v.37, no.4, pp 350 - 357 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000429812400004 | - |
dc.identifier.scopusid | 2-s2.0-85044413779 | - |
dc.citation.endPage | 357 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 350 | - |
dc.citation.title | HUMAN & EXPERIMENTAL TOXICOLOGY | - |
dc.citation.volume | 37 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Bone mineral density | - |
dc.subject.keywordAuthor | cadmium | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.subject.keywordPlus | VITAMIN-D | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | LEAD | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | NUTRIENTS | - |
dc.subject.keywordPlus | HEALTH | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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