Factors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer’s Diseaseopen access
- Authors
- 나해리; 박문호; 김상윤; 양동원; 최성혜; 양현덕; 양영순; 한현정; 이정석; 윤영철; 고성호; 김정은; 구본대; 김희진; 박경원; 김은주; 윤보라; 박기정
- Issue Date
- 2015
- Publisher
- 대한치매학회
- Keywords
- rivastigmine transdermal patch; Alzheimer’s disease; tolerability
- Citation
- Dementia and Neurocognitive Disorders(대한치매학회지), v.14, no.1, pp 31 - 38
- Pages
- 8
- Journal Title
- Dementia and Neurocognitive Disorders(대한치매학회지)
- Volume
- 14
- Number
- 1
- Start Page
- 31
- End Page
- 38
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11112
- DOI
- 10.12779/dnd.2015.14.1.31
- ISSN
- 1738-1495
- Abstract
- Background and Purpose The one-day rivastigmine patch is reportedly well tolerated and has minimal side effects. However, Asian patientsshow more side effects than those in Western countries. We evaluated tolerability of the rivastigmine patch in South Korean patientswith Alzheimer’s disease (AD) and the specific factors affecting adverse events of the skin.
Methods A 6-month, open labeled, multi-centered, observational study was carried out in 440 patients with probable AD from July 2009to September 2010 (NCT01312363).
Results A total of 25.9% of the patients experienced adverse skin events at the rivastigmine patch application site and 17.0% discontinuedtreatment due to adverse events at the skin application site. The most common adverse events were itching and erythema. Patients with an allergichistory and users of electric heating appliances reported skin discomfort. Older age was associated with discontinuing treatment.
Conclusions These results suggest that the rivastigmine patch induced some adverse skin events and may contribute to understanding andimproving skin tolerability to the rivastigmine patch.
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