Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Rae | - |
dc.contributor.author | Ho, Myoung Jin | - |
dc.contributor.author | Lee, Eugene | - |
dc.contributor.author | Lee, Joon Woo | - |
dc.contributor.author | Choi, Young Wook | - |
dc.contributor.author | Kang, Myung Joo | - |
dc.date.available | 2019-03-08T20:38:42Z | - |
dc.date.issued | 2015-08-24 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11410 | - |
dc.description.abstract | Positively surface-charged poly(lactide-co-glycolide) (PLGA)/Eudragit RL nanoparticles (NPs) were designed to increase retention time and sustain release profile in joints after intra-articular injection, by forming micrometer-sized electrostatic aggregates with hyaluronic acid, an endogenous anionic polysaccharide found in high amounts in synovial fluid. The cationic NPs consisting of PLGA, Eudragit RL, and polyvinyl alcohol were fabricated by solvent evaporation technique. The NPs were 170.1 nm in size, with a zeta potential of 21.3 mV in phosphate-buffered saline. Hyperspectral imaging (CytoViva (R)) revealed the formation of the micrometer-sized filamentous aggregates upon admixing, due to electrostatic interaction between NPs and the polysaccharides. NPs loaded with a fluorescent probe (1,1'-dioctadecyl-3,3,3', 3' tetramethylindotricarbocyanine iodide, DiR) displayed a significantly improved retention time in the knee joint, with over 50% preservation of the fluorescent signal 28 days after injection. When DiR solution was injected intra-articularly, the fluorescence levels rapidly decreased to 30% of the initial concentration within 3 days in mice. From these findings, we suggest that PLGA-based cationic NPs could be a promising tool for prolonged delivery of therapeutic agents in joints selectively. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.title | Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint | - |
dc.type | Article | - |
dc.identifier.doi | 10.2147/IJN.S88363 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.10, pp 5263 - 5271 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000360058200002 | - |
dc.identifier.scopusid | 2-s2.0-84940055980 | - |
dc.citation.endPage | 5271 | - |
dc.citation.startPage | 5263 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 뉴질랜드 | - |
dc.subject.keywordAuthor | PLGA | - |
dc.subject.keywordAuthor | Eudragit RL | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | cationic nanoparticles | - |
dc.subject.keywordAuthor | intra-articular injection | - |
dc.subject.keywordAuthor | electrostatic interaction | - |
dc.subject.keywordPlus | DRUG-DELIVERY SYSTEMS | - |
dc.subject.keywordPlus | POLYMERIC MICROSPHERES | - |
dc.subject.keywordPlus | ARTICULAR-CARTILAGE | - |
dc.subject.keywordPlus | PLGA NANOPARTICLES | - |
dc.subject.keywordPlus | RABBIT KNEE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | OSTEOARTHRITIS | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | ULTRASTRUCTURE | - |
dc.subject.keywordPlus | PHAGOCYTOSIS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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