Dual matrilineal geographic distribution of Korean type 2 diabetes mellitus-associated-11,377 G adiponectin allele
DC Field | Value | Language |
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dc.contributor.author | Choi, Jee-Hye | - |
dc.contributor.author | Min, Na Young | - |
dc.contributor.author | Park, Sang Kil | - |
dc.contributor.author | Gavaachimed, Lkhagvasuren | - |
dc.contributor.author | Ko, Young Jong | - |
dc.contributor.author | Han, Sung Hoon | - |
dc.contributor.author | Kim, Kyung Yong | - |
dc.contributor.author | Kim, Kijung | - |
dc.contributor.author | Lee, Kwang Ho | - |
dc.contributor.author | Park, Ae Ja | - |
dc.date.available | 2019-03-08T20:41:50Z | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.issn | 1791-3004 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11545 | - |
dc.description.abstract | The present study was performed to identify the susceptible single nucleotide polymorphisms (SNPs) for the prediction of Korean type 2 diabetes mellitus (T2DM) and to clarify the matrilineal origin of Korean T2DM-specific SNPs. Fourteen SNPs from the adiponectin (ADIPOQ), hepatocyte nuclear factor 4 alpha, phosphoenolpyruvate carboxykinase 1 and glucokinase genes in the Korean population were analyzed. Only one SNP, -11,377 C/G on the ADIPOQ gene, was finally determined to be responsible for the incidence of Korean T2DM (P=0.028). The G-T-T-A haplotype at positions -11,377, +45, +276 and +349 on the ADIPOQ gene was also associated with a high incidence of Korean T2DM (P=0.023). In addition, the susceptibility of Korean individuals to T2DM appears to be affected by their matrilineal origin. Of note, the group of Southern origin, consisting of mitochondrial DNA macrohaplogroups F and R, was predisposed to T2DM, whereas the group of Northern origin, consisting of haplogroups A and Y, was resistant to T2DM. This implied that the differential genetics between the two groups, which were formed from the initial peopling of the proto-Korean population via Southern and Northern routes to the present time, may explain their differing susceptibility to T2DM. In conclusion, from Southern Asia Northward, a matrilineal origin of Korean individuals appears to be responsible for the prevalence Of Korean T2DM caused by the -11,377 G allele. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.title | Dual matrilineal geographic distribution of Korean type 2 diabetes mellitus-associated-11,377 G adiponectin allele | - |
dc.type | Article | - |
dc.identifier.doi | 10.3892/mmr.2014.2639 | - |
dc.identifier.bibliographicCitation | MOLECULAR MEDICINE REPORTS, v.10, no.6, pp 2993 - 3002 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000345947900031 | - |
dc.identifier.scopusid | 2-s2.0-84914165984 | - |
dc.citation.endPage | 3002 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2993 | - |
dc.citation.title | MOLECULAR MEDICINE REPORTS | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 그리이스 | - |
dc.subject.keywordAuthor | type 2 diabetes mellitus | - |
dc.subject.keywordAuthor | single nucleotide polymorphism | - |
dc.subject.keywordAuthor | haplotype | - |
dc.subject.keywordAuthor | adiponectin | - |
dc.subject.keywordAuthor | hepatocyte nuclear factor 4 alpha | - |
dc.subject.keywordAuthor | phosphoenolpyruvate carboxykinase 1 | - |
dc.subject.keywordAuthor | glucokinase | - |
dc.subject.keywordAuthor | mitochondrial DNA | - |
dc.subject.keywordPlus | SINGLE-NUCLEOTIDE POLYMORPHISMS | - |
dc.subject.keywordPlus | MITOCHONDRIAL-DNA DIVERSITY | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | APM1 GENE | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | PLASMA ADIPONECTIN | - |
dc.subject.keywordPlus | PROMOTER REGION | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | PROXIMAL PROMOTER | - |
dc.subject.keywordPlus | ASIAN POPULATIONS | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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