Classification of ginseng berry (Panax ginseng CA MEYER) extract using H-1 NMR spectroscopy and its inhibition of lipid accumulation in 3 T3-L1 cells
- Authors
- Yang, Seung Ok; Park, Hae Ran; Sohn, Eun Suk; Lee, Sang Won; Kim, Hyung Don; Kim, Young Chang; Kim, Kee Hong; Na, Sae Won; Choi, Hyung-Kyoon; Arasu, Mariadhas Valan; Kim, Young Ock
- Issue Date
- 24-Nov-2014
- Publisher
- BIOMED CENTRAL LTD
- Keywords
- Panax ginseng berry; Obesity; Metabolite profiling; Maturation
- Citation
- BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.14, no.1
- Journal Title
- BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
- Volume
- 14
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11585
- DOI
- 10.1186/1472-6882-14-455
- ISSN
- 1472-6882
- Abstract
- Background: Panax ginseng is a famous traditional medicine in Korea for its beneficial effect on obesity, cardiac and liver associated diseases. The aim of this study was to investigate the metabolite in Panax ginseng (P. ginseng, Aralicaceae) berries depending on the ripen stages and evaluate its potential inhibition on adipocyte differentiation in 3 T3-L1 cells. Methods: Different ripening stage samples of P. ginseng berry were analyzed through global metabolite profiling by NMR spectroscopy. Lipid accumulation in the cells was analyzed by Oil Red O staining. Results: The PLS-DA clearly distinguished P. ginseng berry extract (PGBE) according to the partial ripe (PR), ripe(R) and fully ripe (FR) stage. Lipid accumulation of PGBE was examined by measuring triglyceride content and Oil-Red O staining. These results suggested that the FR stage of PGBE decrease in lipid accumulation during adipocyte differentiation and the amount of threonine, asparagine, fumarate, tyraine, tyrosine, and phenylalanine increased with longer ripening of ginseng berries. Conclusion: Metabolite profiling of P. ginseng was identified by H-1 NMR spectra. P. ginseng extract efficiently inhibits adipogenesis in 3 T3-L1 adipocytes concluded that the P. ginseng has the antiobesity properties.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.