The association between KL polymorphism and prostate cancer risk in Korean patients
DC Field | Value | Language |
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dc.contributor.author | Kim, Hae Jong | - |
dc.contributor.author | Lee, Jaehyouk | - |
dc.contributor.author | Lee, Shin Young | - |
dc.contributor.author | Cheong, Hyun Sub | - |
dc.contributor.author | Kye, Young-Sik | - |
dc.contributor.author | Kim, Wonyong | - |
dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Myung, Soon Chul | - |
dc.date.available | 2019-03-08T20:57:26Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.issn | 1573-4978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11642 | - |
dc.description.abstract | The Klotho (KL) gene is a classical "aging suppressor'' gene. Although recent studies have shown that KL participates in the progression of several types of human cancers, the relationship between KL polymorphism and prostate cancer was unknown. The present study aimed to investigate the association between KL genetic polymorphisms and prostate cancer. Twenty-five common single nucleotide polymorphisms (SNPs) in KL gene (including KL gene polymorphism C1818T in exon 4) were assessed in 272 prostate cancer cases and 173 controls. Single-locus analyses were conducted using unconditional logistic regression. In addition, we did a haplotype analysis for the 25 KL SNPs tested. CC genotype of C1548T KL polymorphism had approximately twofold increased prostate cancer risk compared with the homozygous genotype TT and heterozygote CT (odds ratio 1.85 [95 % CI, 1.09-3.12], P = 0.02). We also found that non-T allele carriers had significantly higher prostate cancer risk associated with the prostate cancer clinical characteristics (tumor stage or Gleason score). Our findings suggested that the C1548T polymorphism of KL gene is associated with the prostate cancer and may act as a risk factor for the development of prostate cancer. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | The association between KL polymorphism and prostate cancer risk in Korean patients | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s11033-014-3647-y | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.41, no.11, pp 7595 - 7606 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000344101300059 | - |
dc.identifier.scopusid | 2-s2.0-84917670970 | - |
dc.citation.endPage | 7606 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 7595 | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 41 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Klotho | - |
dc.subject.keywordAuthor | Single nucleotide polymorphism | - |
dc.subject.keywordAuthor | Prostate cancer | - |
dc.subject.keywordPlus | BONE-MINERAL DENSITY | - |
dc.subject.keywordPlus | TRANSCRIPTS ENCODING MEMBRANE | - |
dc.subject.keywordPlus | KLOTHO GENE POLYMORPHISM | - |
dc.subject.keywordPlus | GLUCOSE-METABOLISM | - |
dc.subject.keywordPlus | MOLECULAR-CLONING | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | DISEQUILIBRIUM | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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