Hydrogel-Based Ultra-moisturizing Cream Formulation for Skin Hydration and Enhanced Dermal Drug Delivery
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Gon | - |
dc.contributor.author | Kim, Sung Rae | - |
dc.contributor.author | Cho, Hye In | - |
dc.contributor.author | Kang, Mean Hyung | - |
dc.contributor.author | Yeom, Dong Woo | - |
dc.contributor.author | Lee, Seo Hyun | - |
dc.contributor.author | Lee, Sangkil | - |
dc.contributor.author | Choi, Young Wook | - |
dc.date.available | 2019-03-08T20:59:47Z | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.issn | 1347-5215 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11754 | - |
dc.description.abstract | To develop an external vehicle for skin hydration and enhanced dermal drug delivery, a hydrogel-based ultra-moisturizing cream (HUMC) was successfully formulated with carbopol 934P, urea, Tinocare GL, grape seed oil, and other excipients. The HUMC showed plastic flow behavior due to a gel structure with a cream base. Different types of drug-free vehicles such as a hydrogel, conventional cream (CC), and three HUMCs were prepared and subjected to an in vivo skin hydration test on a hairless mouse using a corneometer. Hydration effect (Delta AU) was in the order of HUMC2>HUMC1 >= CC>HUMC3>hydrogel. Using nile red (NR) and 5-carboxyfluorescein (5-CF) as lipophilic and hydrophilic fluorescent probes, respectively, in vitro skin permeation and accumulation studies were conducted using Franz diffusion cells. The values of steady-state flux (J(ss), ng/h/cm(2)) were obtained: 74.8 (CC), 145.6 (HUMC1), and 161.9 (HUMC2) for NR delivery; 6.8 (CC), 8.3 (HUMC1), and 10.9 (HUMC2) for 5-CF delivery. The amounts retained in the skin at 12 h (Q(r), ng/cm(2)) were determined: 86.4 (CC) and 102.0 (HUMC2) for NR; and 70.1 (CC) and 195.6 (HUMC2) for 5-CF. Confocal microscopy was used to visualize the distribution of the fluorescent probes. NR tended to be localized into the deeper part of the skin with adipose tissue whereas 5-CF localized in the upper layer of the skin. Thus we propose that HUMC2 is an efficacious vehicle for skin hydration and enhances dermal delivery of lipophilic and hydrophilic drugs. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.title | Hydrogel-Based Ultra-moisturizing Cream Formulation for Skin Hydration and Enhanced Dermal Drug Delivery | - |
dc.type | Article | - |
dc.identifier.doi | 10.1248/bpb.b14-00458 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.37, no.10, pp 1674 - 1682 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000342479800014 | - |
dc.identifier.scopusid | 2-s2.0-84908110059 | - |
dc.citation.endPage | 1682 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1674 | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 37 | - |
dc.type.docType | Article | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | hydrogel-based cream | - |
dc.subject.keywordAuthor | moisturizer | - |
dc.subject.keywordAuthor | skin hydration | - |
dc.subject.keywordAuthor | topical delivery | - |
dc.subject.keywordAuthor | skin permeation | - |
dc.subject.keywordAuthor | skin distribution | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | ELECTRON-MICROSCOPY | - |
dc.subject.keywordPlus | BARRIER FUNCTION | - |
dc.subject.keywordPlus | FATTY-ACIDS | - |
dc.subject.keywordPlus | VEHICLES | - |
dc.subject.keywordPlus | UREA | - |
dc.subject.keywordPlus | PENETRATION | - |
dc.subject.keywordPlus | PERMEATION | - |
dc.subject.keywordPlus | DRY | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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