Negative regulation of peroxiredoxin 6 (Prdx 6) transcription by nuclear oncoprotein DEK during leukemia cell differentiation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kee-Beom | - |
dc.contributor.author | Chae, Yun-Cheol | - |
dc.contributor.author | Han, Arim | - |
dc.contributor.author | Kang, Joo-Young | - |
dc.contributor.author | Jung, Hyeonsoo | - |
dc.contributor.author | Park, Jin Woo | - |
dc.contributor.author | Hahm, Ja Young | - |
dc.contributor.author | Kim, Seryeon | - |
dc.contributor.author | Seo, Sang-Beom | - |
dc.date.available | 2019-03-08T21:01:13Z | - |
dc.date.issued | 2014-09 | - |
dc.identifier.issn | 1976-8354 | - |
dc.identifier.issn | 2151-2485 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11823 | - |
dc.description.abstract | The oncogene protein DEK is an abundant and ubiquitous nuclear protein with implications in acute myelogenous leukemia, as translocation which results in the formation of a DEK-CAN fusion protein. In a previous study, we have identified that DEK negatively regulated peroxiredoxin 6 (Prdx 6) transcription synergistically with the p65 subunit of NF-kappa B. In this study, we further investigated DEK-mediated transcriptional regulation of Prdx 6 during leukemia cell differentiation. Using Chromatin Immunoprecipitation analysis and Prdx 6 reporter assays, we found that DEK operated as a negative regulator of Prdx 6 transcription during leukemia cell differentiation. DEK was highly expressed and recruited to Prdx 6 promoter along with p65 and repressed transcription after leukemia cell differentiation. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Negative regulation of peroxiredoxin 6 (Prdx 6) transcription by nuclear oncoprotein DEK during leukemia cell differentiation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/19768354.2014.950605 | - |
dc.identifier.bibliographicCitation | ANIMAL CELLS AND SYSTEMS, v.18, no.5, pp 318 - 323 | - |
dc.identifier.kciid | ART001922697 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000343811900005 | - |
dc.identifier.scopusid | 2-s2.0-84920191284 | - |
dc.citation.endPage | 323 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 318 | - |
dc.citation.title | ANIMAL CELLS AND SYSTEMS | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | DEK | - |
dc.subject.keywordAuthor | differentiation | - |
dc.subject.keywordAuthor | leukemia | - |
dc.subject.keywordAuthor | Prdx 6 | - |
dc.subject.keywordPlus | PROTOONCOGENE PROTEIN DEK | - |
dc.subject.keywordPlus | ACUTE MYELOID-LEUKEMIA | - |
dc.subject.keywordPlus | 1-CYS PEROXIREDOXIN | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CHROMATIN | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | FUSION | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Zoology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Zoology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.