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Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Disease Activity Biomarker in Patients with Rheumatoid Arthritis

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dc.contributor.authorHa, You Jung-
dc.contributor.authorKang, Eun-Jin-
dc.contributor.authorLee, Sang-Won-
dc.contributor.authorLee, Soo-Kon-
dc.contributor.authorPark, Yong-Beom-
dc.contributor.authorSong, Jung-Soo-
dc.contributor.authorChoi, Sang Tae-
dc.date.available2019-03-08T21:36:51Z-
dc.date.issued2014-09-
dc.identifier.issn1011-8934-
dc.identifier.issn1598-6357-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11905-
dc.description.abstractOur study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha). Our study included 69 patients with RA and 48 age- and sexmatched healthy controls. Serum concentrations of TNF-alpha and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8 +/- 14.4 vs. 22.2 +/- 6.1 ng/mL; P < 0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (gamma = 0.671; gamma = 0.612; and gamma = 0.601, P < 0.001, respectively), but not with serum TNF-a levels. Serum LRG levels in patients with an active disease status (DAS28 >= 2.6) were significantly higher than those in remission (DAS28 < 2.6) (36.45 +/- 14.36 vs. 24.63 +/- 8.81 ng/mL; P < 0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-alpha and it may be a novel biomarker for assessing inflammatory activity in patients with RA.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisherKOREAN ACAD MEDICAL SCIENCES-
dc.titleUsefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Disease Activity Biomarker in Patients with Rheumatoid Arthritis-
dc.typeArticle-
dc.identifier.doi10.3346/jkms.2014.29.9.1199-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.9, pp 1199 - 1204-
dc.identifier.kciidART001910076-
dc.description.isOpenAccessN-
dc.identifier.wosid000344321800004-
dc.identifier.scopusid2-s2.0-84929939672-
dc.citation.endPage1204-
dc.citation.number9-
dc.citation.startPage1199-
dc.citation.titleJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.citation.volume29-
dc.type.docTypeArticle-
dc.publisher.location대한민국-
dc.subject.keywordAuthorLeucine-Rich Alpha-2-Glycoprotein-
dc.subject.keywordAuthorArthritis, Rheumatoid-
dc.subject.keywordAuthorDisease Activity-
dc.subject.keywordAuthorTumor Necrosis Factor-alpha-
dc.subject.keywordPlusC-REACTIVE PROTEIN-
dc.subject.keywordPlusALPHA-2-GLYCOPROTEIN-
dc.subject.keywordPlusRECOMMENDATIONS-
dc.subject.keywordPlusCLASSIFICATION-
dc.subject.keywordPlusINTERLEUKIN-6-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusCRITERIA-
dc.subject.keywordPlusMARKER-
dc.subject.keywordPlusTARGET-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
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