Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Disease Activity Biomarker in Patients with Rheumatoid Arthritis
DC Field | Value | Language |
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dc.contributor.author | Ha, You Jung | - |
dc.contributor.author | Kang, Eun-Jin | - |
dc.contributor.author | Lee, Sang-Won | - |
dc.contributor.author | Lee, Soo-Kon | - |
dc.contributor.author | Park, Yong-Beom | - |
dc.contributor.author | Song, Jung-Soo | - |
dc.contributor.author | Choi, Sang Tae | - |
dc.date.available | 2019-03-08T21:36:51Z | - |
dc.date.issued | 2014-09 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11905 | - |
dc.description.abstract | Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha). Our study included 69 patients with RA and 48 age- and sexmatched healthy controls. Serum concentrations of TNF-alpha and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8 +/- 14.4 vs. 22.2 +/- 6.1 ng/mL; P < 0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (gamma = 0.671; gamma = 0.612; and gamma = 0.601, P < 0.001, respectively), but not with serum TNF-a levels. Serum LRG levels in patients with an active disease status (DAS28 >= 2.6) were significantly higher than those in remission (DAS28 < 2.6) (36.45 +/- 14.36 vs. 24.63 +/- 8.81 ng/mL; P < 0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-alpha and it may be a novel biomarker for assessing inflammatory activity in patients with RA. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Disease Activity Biomarker in Patients with Rheumatoid Arthritis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3346/jkms.2014.29.9.1199 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.9, pp 1199 - 1204 | - |
dc.identifier.kciid | ART001910076 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000344321800004 | - |
dc.identifier.scopusid | 2-s2.0-84929939672 | - |
dc.citation.endPage | 1204 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1199 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 29 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Leucine-Rich Alpha-2-Glycoprotein | - |
dc.subject.keywordAuthor | Arthritis, Rheumatoid | - |
dc.subject.keywordAuthor | Disease Activity | - |
dc.subject.keywordAuthor | Tumor Necrosis Factor-alpha | - |
dc.subject.keywordPlus | C-REACTIVE PROTEIN | - |
dc.subject.keywordPlus | ALPHA-2-GLYCOPROTEIN | - |
dc.subject.keywordPlus | RECOMMENDATIONS | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | INTERLEUKIN-6 | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | TARGET | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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