Fucoidan Promotes the Reconstruction of Skin Equivalents
DC Field | Value | Language |
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dc.contributor.author | Song, Yu Seok | - |
dc.contributor.author | Li, Hailan | - |
dc.contributor.author | Balcos, Marie Carmel | - |
dc.contributor.author | Yun, Hye-Young | - |
dc.contributor.author | Baek, Kwang Jin | - |
dc.contributor.author | Kwon, Nyoun Soo | - |
dc.contributor.author | Choi, Hye-Ryung | - |
dc.contributor.author | Park, Kyoung-Chan | - |
dc.contributor.author | Kim, Dong-Seok | - |
dc.date.available | 2019-03-08T21:38:51Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11994 | - |
dc.description.abstract | In this study we investigated the effects of fucoidan on the proliferation of fibroblasts and the reconstruction of a skin equivalent (SE). Fucoidan significantly stimulated the proliferation of CCD-25Sk human fibroblasts and Western blot analysis demonstrated that fucoidan markedly increased the expression of cyclin D1 and decreased the expression of p27. Fucoidan was used to reconstruct SE. Immunohistochemical staining showed that the addition of fucoidan to dermal equivalents increased expression of proliferating cell nuclear antigen (PCNA) and p63. In addition, expression of alpha 6-integrin was significantly increased by fucoidan, whereas expression of beta 1-integrin, type 1 collagen, elastin, fibronectin did not markedly change. These results suggest that fucoidan has positive effects on epidermal reconstruction and will therefore be beneficial in the reconstruction of SE. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | Fucoidan Promotes the Reconstruction of Skin Equivalents | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2014.18.4.327 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.18, no.4, pp 327 - 331 | - |
dc.identifier.kciid | ART001902187 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000340579000007 | - |
dc.identifier.scopusid | 2-s2.0-84907197816 | - |
dc.citation.endPage | 331 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 327 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Fibroblasts | - |
dc.subject.keywordAuthor | Fucoidan | - |
dc.subject.keywordAuthor | Proliferation | - |
dc.subject.keywordAuthor | Skin equivalent | - |
dc.subject.keywordPlus | MELANOMA-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | P63 | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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