Comparison of the Impact of High-Flux Dialysis on Mortality in Hemodialysis Patients with and without Residual Renal Function
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyung Wook | - |
dc.contributor.author | Kim, Su-Hyun | - |
dc.contributor.author | Kim, Young Ok | - |
dc.contributor.author | Jin, Dong Chan | - |
dc.contributor.author | Song, Ho Chul | - |
dc.contributor.author | Choi, Euy Jin | - |
dc.contributor.author | Kim, Yong-Lim | - |
dc.contributor.author | Kim, Yon-Su | - |
dc.contributor.author | Kang, Shin-Wook | - |
dc.contributor.author | Kim, Nam-Ho | - |
dc.contributor.author | Yang, Chul Woo | - |
dc.contributor.author | Kim, Yong Kyun | - |
dc.date.available | 2019-03-08T21:42:20Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12140 | - |
dc.description.abstract | Background: The effect of flux membranes on mortality in hemodialysis (HD) patients is controversial. Residual renal function (RRF) has shown to not only be as a predictor of mortality but also a contributor to beta 2-microglobulin clearance in HD patients. Our study aimed to determine the interaction of residual renal function with dialyzer membrane flux on mortality in HD patients. Methods: HD Patients were included from the Clinical Research Center registry for End Stage Renal Disease, a prospective observational cohort study in Korea. Cox proportional hazards regression models were used to study the association between use of high-flux dialysis membranes and all-cause mortality with RRF and without RRF. The primary outcome was all-cause mortality. Results: This study included 893 patients with 24 h-residual urine volume >= 100 ml (569 and 324 dialyzed using low-flux and high-flux dialysis membranes, respectively) and 913 patients with 24 h-residual urine volume < 100 ml (570 and 343 dialyzed using low-flux and high-flux dialysis membranes, respectively). After a median follow-up period of 31 months, mortality was not significantly different between the high and low-flux groups in patients with 24 h-residual urine volume >= 100 ml (HR 0.86, 95% CI, 0.38-1.95, P = 0.723). In patients with 24 h-residual urine volume < 100 ml, HD using high-flux dialysis membrane was associated with decreased mortality compared to HD using low-flux dialysis membrane in multivariate analysis (HR 0.40, 95% CI, 0.21-0.78, P = 0.007). Conclusions: Our data showed that HD using high-flux dialysis membranes had a survival benefit in patients with 24 h-residual urine volume < 100 ml, but not in patients with 24 h-residual urine volume >= 100 ml. These findings suggest that high-flux dialysis rather than low-flux dialysis might be considered in HD patients without RRF. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Comparison of the Impact of High-Flux Dialysis on Mortality in Hemodialysis Patients with and without Residual Renal Function | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0097184 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.9, no.6 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000341869000005 | - |
dc.identifier.scopusid | 2-s2.0-84902603057 | - |
dc.citation.number | 6 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | DIALYZER MEMBRANE-CHARACTERISTICS | - |
dc.subject.keywordPlus | MAINTENANCE HEMODIALYSIS | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | REUSE | - |
dc.subject.keywordPlus | BETA(2)-MICROGLOBULIN | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | HEMO | - |
dc.subject.keywordPlus | RISK | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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