Clinical significance of the BRAF(V600E) mutation in multifocal papillary thyroid carcinoma in Korea
- Authors
- Ahn, Hwa Young; Chung, Yun Jae; Kim, Byung Seup; Kang, Kyung Ho; Seok, Ju Won; Kim, Hee Sung; Park, Sung Jun; Cho, Bo Youn
- Issue Date
- Apr-2014
- Publisher
- MOSBY-ELSEVIER
- Citation
- SURGERY, v.155, no.4, pp 689 - 695
- Pages
- 7
- Journal Title
- SURGERY
- Volume
- 155
- Number
- 4
- Start Page
- 689
- End Page
- 695
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12345
- DOI
- 10.1016/j.surg.2013.12.025
- ISSN
- 0039-6060
- Abstract
- Background. We examined the fequency of the BRAF(V600E) mutation and compared the clinicopathologic features based on the BRAF(V600E) mutation status in multifocal papillary thyroid carcinoma (PTC). Methods. A total 85 patients who were diagnosed with multifocal PTC were enrolled. We confirmed the status of the BRAF(V600E) mutation in each tumor focus by the real-time polymerase chain reaction technique. Results. Among the 85 patients, 49 (57.6%), 34 (40.0%), and 2 (2.4%) patients were determined to have all BRAF(V600E)-positive, mixed BRAF(V600E), and all BRAF(V600E)-negative in their tumor foci, respectively. When we compared clinicopathologic features according to the BRAF(V600E) mutation status of the dominant tumor, the BRAF(V600E)-positive group (n = 70) showed more extrathyroidal invasion in the dominant tumor (32.9% vs 6.7%, P = .041) and more lymph node metastasis (67.2% vs 40.0%, P =.049) than the BRAF(V600E)-negative group (n = 15). Considering all tumor foci, the all BRAF(V600E) mutation group exhibited a younger population (P = .039), showed increased extrathyroidal invasion. (38.8% vs 14.7%, P = .017) and lymph node metastasis (71.4% vs 48.4%, P = .038), and received more radioactive iodine therapy (79.2% vs 52.9%, P = .012) than the mixed BRAF(V600E) mutation group. A larger tumor size and heavier preoperative bogy weight was positively correlated with the relative expression of BRAF(V600E) mutation calculated by 2(-Delta Delta Ct) method. Conclusion. Most of the Korean patients with multifocal PTC had the BRAF(V600E) mutation in one or more tumor foci, and all BRAF(V600E)-positive multifocal PTC showed more aggressive features.
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