The Effects of Barrier Agents in Postoperative Pelvic Adhesion Formation: A Comparative Study of a Temperature-Sensitive Poloxamer-Based Solution/Gel and a Hyaluronic Acid-Based Solution in a Rat Uterine Horn Model
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyeon-Ji | - |
dc.contributor.author | Kang, Hyun | - |
dc.contributor.author | Kim, Mi-Kyung | - |
dc.contributor.author | Han, Seung-Su | - |
dc.date.available | 2019-01-22T14:13:11Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 1092-6429 | - |
dc.identifier.issn | 1557-9034 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1240 | - |
dc.description.abstract | Objective: The aim is to evaluate the efficacy of poloxamer/alginate/CaCl2 mixture (PACM) solution/gel and hyaluronic acid/carboxymethylcellulose (HA-CMC) solution for reducing pelvic adhesion in a rat uterine horn model. Study Design: A total of 48 females, Sprague Dawley rats, were divided into three groups according to the applied materials. A uterine horn adhesion model was created. The control group (group CO; n=16) received no special materials except saline infusion. The experimental groups were treated with 1.0mL HA-CMC solution (group HA-CMC; n=16) or 1.0mL PACM solution/gel (group PACM; n=16). Adhesion scores were evaluated with macroscopic, microscopic, and immunohistochemistry grading 14 days postoperatively. Results: Macroscopic adhesion scores, including extent, severity, and total scores in group HA-CMC and group PACM, were significantly lower than those in group CO (P<.001). Among these three categories of scoring, group PACM had a significantly lower score than did group HA-CMC in adhesion severity (P=.025). In the microscopic adhesion score analysis, the fibrosis scores in group HA-CMC and group PACM were also significantly lower than that of group CO. In group PACM, the fibrosis score was significantly lower than that of group HA-CMC. There were no statistical differences across all three groups in the microscopic inflammation and immunohistochemistry staining. Conclusion: Both HA-CMC solution and PACM solution/gel effectively reduced adhesion formation. PACM solution/gel was superior to HA-CMC solution in preventing pelvic adhesion, especially in adhesion severity and microscopic fibrosis. | - |
dc.format.extent | 6 | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.title | The Effects of Barrier Agents in Postoperative Pelvic Adhesion Formation: A Comparative Study of a Temperature-Sensitive Poloxamer-Based Solution/Gel and a Hyaluronic Acid-Based Solution in a Rat Uterine Horn Model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1089/lap.2017.0404 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES, v.28, no.2, pp 134 - 139 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000424878300003 | - |
dc.identifier.scopusid | 2-s2.0-85041718331 | - |
dc.citation.endPage | 139 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 134 | - |
dc.citation.title | JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES | - |
dc.citation.volume | 28 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | adhesion prevention | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | pelvic adhesion | - |
dc.subject.keywordAuthor | poloxamer | - |
dc.subject.keywordPlus | GYNECOLOGICAL SURGERY | - |
dc.subject.keywordPlus | RABBIT MODEL | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | REDUCTION | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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